Thiol-PEG3-propionic acid
CAS No.: 1347750-82-6
Cat No.: BP-501558
Purity: >95%
4.5 
Thiol-PEG3-propionic acid is a heterobifunctional PEG-based linker featuring a terminal thiol for chemoselective conjugation and a carboxylic acid for subsequent coupling to amine- or hydrazide-bearing partners. Structurally, it comprises a short, flexible polyethylene glycol segment (PEG3) connected to a propionic acid motif, providing a defined linker length and hydrophilicity that can reduce steric congestion and help maintain productive geometry between PROTAC components. In targeted protein degradation design, the thiol handle enables attachment to electrophilic warheads or to cysteine-reactive surfaces, while the terminal carboxyl group can be used to form amide bonds with ligands or to introduce an attachment point for further linker elaboration. Its value lies in offering a practical, chemically versatile PEG spacer that supports modular synthesis and optimization of PROTAC architectures, facilitating systematic studies of how linker length and flexibility influence ternary complex formation and degradation efficiency.
Structure of 1347750-82-6
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Thiolic PEG-based linkers are widely used in PROTAC architectures to tune solubility, spacer length, and the effective positioning of ligands for ternary complex formation. Thiol-PEG3-propionic acid provides a functional handle for controlled conjugation while maintaining a flexible, hydrophilic environment that can improve linker compatibility across diverse E3 ligands and target-binding moieties. The detailed structural and synthetic considerations are described below.
Structure: Thiol-PEG3-propionic acid is a polyethylene glycol spacer terminating in a thiol and a carboxylic acid. It contains ether linkages within the PEG chain, a thiofunctional group for conjugation, and a propionic acid moiety for further coupling. The combination confers high polarity and water-compatible behavior.
Reactivity: The thiol group is suitable for thiol-directed conjugation strategies, including maleimide or activated-ester coupling, typically under mildly basic or neutral conditions to preserve thiol reactivity. The carboxylic acid can be activated for amide bond formation using standard coupling chemistries, often in polar organic solvents with appropriate bases. Protecting groups for thiols are commonly used to control chemoselectivity during stepwise PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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