THP-PEG9-THP
CAS No.: 1809333-14-9
Cat No.: BP-501498
4.5 
THP-PEG9-THP is a homobifunctional PROTAC linker built from two tetrahydropyran (THP) termini connected through a polyethylene glycol (PEG) spacer of approximately nine ethylene oxide units. Structurally, it provides a flexible, hydrophilic chain that can be used to connect two different functional handles (for example, a ligand for an E3 ligase and a ligand for a target protein) while minimizing steric clashes near the binding interfaces. In PROTAC design, the PEG segment acts as a molecular “distance and solubility” element, promoting productive ternary-complex formation by allowing the conjugated ligands to adopt conformations compatible with simultaneous engagement of the target and the E3 ligase. This linker is particularly valuable when longer reach and improved aqueous compatibility are required to sustain degradation potency and to reduce nonspecific aggregation.
Structure of 1809333-14-9
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THP-PEG9-THP is a bifunctional, PEG-based linker designed for assembling PROTACs that require two compatible attachment points for recruiting ligands while maintaining an appropriate spatial relationship. Its ether-rich PEG segment provides conformational flexibility and improved solubility, which can enhance productive ternary complex formation. The THP end groups enable reliable conjugation strategies, and the detailed structural and synthetic considerations are provided below.
Structure: THP-PEG9-THP contains a poly(ethylene glycol) backbone featuring repeating ether linkages, terminated by THP-protected functionalities. The molecule is characterized by flexible C–O and C–C connectivity, with ether oxygen atoms that support hydrogen-bonding interactions. Overall, it is expected to be polar and readily soluble in common organic and mixed solvent systems.
Reactivity: THP-protected groups are commonly used to control chemoselectivity during PROTAC synthesis; deprotection is typically performed under acidic conditions to reveal reactive alcohol or related handle(s) for subsequent coupling. Linker incorporation into PROTACs generally follows standard conjugation logic such as ester/ether formation or nucleophilic substitution, using appropriate coupling reagents and base/activator systems. Solvent choice is guided by PEG solubility and compatibility with the deprotection and coupling steps, while mild temperatures help preserve sensitive ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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