Name: Tos-PEG3-alcohol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Solubility

In Ethanol: 100 mg/mL (328.56 mM; Need ultrasonic)<br/>In DMSO: 100 mg/mL (328.56 mM; Need ultrasonic and warming)<br/>In H2O: 10 mg/mL (32.86 mM; Need ultrasonic)

Appearance

Liquid

Storage

Pure form, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-(2-hydroxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate

Synonyms

PEG3-Tos; 2-(2-(2-Hydroxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate

Boiling Point

460.0±35.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

RSUCRUOTLCQWFX-UHFFFAOYSA-N

InChI

InChI=1S/C13H20O6S/c1-12-2-4-13(5-3-12)20(15,16)19-11-10-18-9-8-17-7-6-14/h2-5,14H,6-11H2,1H3

SMILES

CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCO

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	3.2856 mL	16.4279 mL	32.8558 mL
5 mM	0.6571 mL	3.2856 mL	6.5712 mL
10 mM	0.3286 mL	1.6428 mL	3.2856 mL

Tos-PEG3-alcohol is a PEG-based linker reagent designed for modular construction of PROTACs, enabling efficient conjugation between a ligand and an E3-recruiting module while improving solubility and reducing steric constraints. Its ether-rich architecture supports flexible linker conformations that can enhance productive ternary complex formation. The points below describe the structure and practical reactivity considerations for PROTAC synthesis and characterization.

Structure: The linker comprises a tosyl-activated PEG chain terminated with an alcohol, featuring an aromatic tosyl group and multiple ether linkages along the polyethylene glycol backbone. The molecule contains sulfonate-derived leaving group functionality and a primary alcohol handle, providing a versatile platform for subsequent bond formation.

Reactivity: The tosyl group enables nucleophilic substitution reactions where the alcohol-containing PEG segment can be transformed into coupling-ready intermediates. PROTAC assembly commonly proceeds via substitution or derivatization steps that link ligands through stable ether or related linkages. Typical conditions use polar aprotic solvents and base-promoted nucleophile generation; reaction rates depend on nucleophile strength and substrate accessibility, and purification is generally required to remove sulfonate byproducts.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂