VH032-O-C2-NH-Boc is an optimized ligand for VHL (Von Hippel-Lindau) E3 ligase, designed for use in PROTAC (Proteolysis Targeting Chimera) research and development. As an "E3 Ligase Ligand," it features a Boc-protected amine and an extended ethylene glycol linker, facilitating conjugation to various target protein ligands. VH032-based ligands are central in designing VHL-recruiting PROTACs, enabling selective ubiquitination and degradation of disease-causing proteins. This compound is ideal for scientists developing next-generation protein degraders targeting oncology, neurodegenerative disorders, and other therapeutic areas.
Structure of 2409007-41-4
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Category
Ligand for E3 Ligase
Molecular Formula
C31H45N5O7S
Molecular Weight
631.78
* For research and manufacturing use only. Not for human or clinical use.
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VH032-O-C2-NH-Boc is a derivative of the well-established VHL (Von Hippel-Lindau) E3 ubiquitin ligase ligand VH032, functionalized with a Boc (tert-butoxycarbonyl)-protected amine at the end of a flexible ethylene linker. The VHL-recruiting chemotype is a cornerstone in PROTAC (Proteolysis Targeting Chimera) and targeted protein degradation research, thanks to its high affinity and selectivity for the VHL E3 ligase complex. This modification enables efficient PROTAC design by offering a convenient functional handle for linker diversification and conjugation strategies.
Mechanism
VH032-O-C2-NH-Boc specifically binds to the VHL E3 ubiquitin ligase, hijacking the natural ubiquitination machinery to direct target proteins for proteasomal degradation. The ethylene linker and terminal Boc-protected amine provide flexible options for conjugation to various ligands targeting proteins of interest. The Boc group not only protects the reactive amine functionality during synthetic processes but also increases the compound's stability and synthetic versatility, streamlining the generation of heterobifunctional degraders.
Applications
VH032-O-C2-NH-Boc is an ideal intermediate for the synthesis of VHL-based PROTACs and related degraders. Key application areas include:
• Construction of VHL-recruiting E3 ligase ligands for PROTACs targeting diverse proteins
• Synthesis of molecular glue degraders and targeted protein degradation tools
• Medicinal chemistry investigations and structure-activity relationship (SAR) studies focused on linker optimization
• Custom conjugation for contract research organizations (CROs) and academic laboratories seeking to explore new protein targets using VHL-mediated degradation.
• High-purity compound verified by HPLC, NMR, and LC-MS
• Consistent batch-to-batch reproducibility with complete QC documentation
• Supplied with COA, MSDS, and analytical data for traceability
• Reliable global shipping with stability-guaranteed packaging
• Dedicated technical support and optional custom synthesis service
• Demonstrates strong binding affinity to CRBN, VHL, or other E3 ligases
• Enables stable E3 ligase recruitment for targeted protein degradation
• Boc-protected amine provides versatile functionalization for advanced PROTAC synthesis.
• Optimized for VHL-based E3 ligase recruitment, enhancing target protein degradation efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
CAS No.: 2409007-41-4
