PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201993	7-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)heptanamide	2732969-77-4	CRBN	FLT3-ITD	Inquiry
Molecular Weight: 747.83 Molecular Formula: C40H42FN9O5 Density: 1.411±0.06 g/cm3 Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
	BPL-201994	4-(5-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-5-oxopent-1-yn-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2852743-61-2	CRBN	FLT3-ITD	Inquiry
Molecular Weight: 714.71 Molecular Formula: C38H31FN8O6 Density: 1.60±0.1 g/cm3 Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
	BPL-201995	4-(6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-6-oxohex-1-yn-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2852743-62-3	CRBN	FLT3-ITD	Inquiry
Molecular Weight: 728.74 Molecular Formula: C39H33FN8O6 Density: 1.58±0.1 g/cm3 Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
	BPL-201996	4-(7-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-7-oxohept-1-yn-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	2852743-63-4	CRBN	FLT3-ITD	Inquiry
Molecular Weight: 742.77 Molecular Formula: C40H35FN8O6 Density: 1.55±0.1 g/cm3 Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
	BPL-201997	(2R,4S)-1-((R)-2-(6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-6-oxohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide	2852743-66-7	VHL	FLT3-ITD	Inquiry
Molecular Weight: 919.09 Molecular Formula: C48H55FN10O6S Density: 1.357±0.06 g/cm3 Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
	BPL-201998	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]propyl]amino]benzamide	2756442-79-0	CRBN	AR	Inquiry
Molecular Weight: 711.22 Molecular Formula: C38H39ClN6O6 Boiling Point: 965.9±65.0°C at 760 Torr Density: 1.40±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-201999	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]butyl]amino]benzamide	2756442-80-3	CRBN	AR	Inquiry
Molecular Weight: 725.25 Molecular Formula: C39H41ClN6O6 Boiling Point: 971.8±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202000	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentyl]amino]benzamide	2756442-81-4	CRBN	AR	Inquiry
Molecular Weight: 739.27 Molecular Formula: C40H43ClN6O6 Boiling Point: 975.4±65.0°C at 760 Torr Density: 1.37±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202001	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]hexyl]amino]benzamide	2756442-82-5	CRBN	AR	Inquiry
Molecular Weight: 753.29 Molecular Formula: C41H45ClN6O6 Boiling Point: 979.1±65.0°C at 760 Torr Density: 1.35±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202002	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]heptyl]amino]benzamide	2756442-83-6	CRBN	AR	Inquiry
Molecular Weight: 767.33 Molecular Formula: C42H47ClN6O6 Boiling Point: 983.1±65.0°C at 760 Torr Density: 1.34±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202003	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]octyl]amino]benzamide	2756442-84-7	CRBN	AR	Inquiry
Molecular Weight: 781.35 Molecular Formula: C43H49ClN6O6 Boiling Point: 987.3±65.0°C at 760 Torr Density: 1.33±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202004	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]ethyl]-1-piperazinyl]benzamide	2756442-85-8	CRBN	AR	Inquiry
Molecular Weight: 766.29 Molecular Formula: C41H44ClN7O6 Boiling Point: 983.5±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202005	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]propyl]-1-piperazinyl]benzamide	2756442-86-9	CRBN	AR	Inquiry
Molecular Weight: 780.33 Molecular Formula: C42H46ClN7O6 Boiling Point: 989.4±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202006	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]butyl]-1-piperazinyl]benzamide	2756442-87-0	CRBN	AR	Inquiry
Molecular Weight: 794.35 Molecular Formula: C43H48ClN7O6 Boiling Point: 992.2±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202007	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentyl]-1-piperazinyl]benzamide	2756442-88-1	CRBN	AR	Inquiry
Molecular Weight: 808.38 Molecular Formula: C44H50ClN7O6 Boiling Point: 996.4±65.0°C at 760 Torr Density: 1.37±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202008	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]benzamide	2756442-89-2	CRBN	AR	Inquiry
Molecular Weight: 739.27 Molecular Formula: C40H43ClN6O6 Boiling Point: 969.8±65.0°C at 760 Torr Density: 1.37±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202009	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]amino]benzamide	2756442-90-5	CRBN	AR	Inquiry
Molecular Weight: 753.29 Molecular Formula: C41H45ClN6O6 Boiling Point: 973.7±65.0°C at 760 Torr Density: 1.35±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202010	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-1-piperazinyl]benzamide	2756442-91-6	CRBN	AR	Inquiry
Molecular Weight: 766.29 Molecular Formula: C41H44ClN7O6 Boiling Point: 983.5±65.0°C at 760 Torr Density: 1.41±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202011	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propyl]-1-piperazinyl]benzamide	2756442-92-7	CRBN	AR	Inquiry
Molecular Weight: 780.33 Molecular Formula: C42H46ClN7O6 Boiling Point: 989.4±65.0°C at 760 Torr Density: 1.39±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.
	BPL-202012	N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butyl]-1-piperazinyl]benzamide	2756442-93-8	CRBN	AR	Inquiry
Molecular Weight: 794.34 Molecular Formula: C43H48ClN7O6 Boiling Point: 992.2±65.0°C at 760 Torr Density: 1.38±0.1 g/cm3 Description: It is a potent and orally bioavailable proteolysis targeting chimera degrader of androgen receptor for the treatment of prostate cancer.