| Structure |
Catalog |
Product Name |
CAS |
E3 Ligase |
Target |
Inquiry |
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)succinamide](https://resource.bocsci.com/structure/2639330-31-5.gif) |
BPL-201973 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)succinamide |
2639330-31-5 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 903.49
Molecular Formula: C44H55ClN10O7S
Boiling Point: 1147.6±65.0°C at 760 Torr
Density: 1.43±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonyl)succinamide](https://resource.bocsci.com/structure/2639330-32-6.gif) |
BPL-201974 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonyl)succinamide |
2639330-32-6 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 917.52
Molecular Formula: C45H57ClN10O7S
Boiling Point: 1137.0±65.0°C at 760 Torr
Density: 1.41±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(10-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decyl)succinamide](https://resource.bocsci.com/structure/2639330-33-7.gif) |
BPL-201975 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(10-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decyl)succinamide |
2639330-33-7 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 931.54
Molecular Formula: C46H59ClN10O7S
Boiling Point: 1139.7±65.0°C at 760 Torr
Density: 1.40±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecyl)succinamide](https://resource.bocsci.com/structure/2639330-34-8.gif) |
BPL-201976 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecyl)succinamide |
2639330-34-8 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 945.57
Molecular Formula: C47H61ClN10O7S
Boiling Point: 1142.7±65.0°C at 760 Torr
Density: 1.39±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)dodecyl)succinamide](https://resource.bocsci.com/structure/2639330-35-9.gif) |
BPL-201977 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)dodecyl)succinamide |
2639330-35-9 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 959.60
Molecular Formula: C48H63ClN10O7S
Boiling Point: 1145.8±65.0°C at 760 Torr
Density: 1.38±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(13-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)tridecyl)succinamide](https://resource.bocsci.com/structure/2639330-36-0.gif) |
BPL-201978 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(13-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)tridecyl)succinamide |
2639330-36-0 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 973.62
Molecular Formula: C49H65ClN10O7S
Boiling Point: 1149.0±65.0°C at 760 Torr
Density: 1.36±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
 |
BPL-201979 |
21-SLF |
2765059-00-3 |
DCAF11 |
FKBP12 |
Inquiry |
|
Molecular Weight: 1154.62
Molecular Formula: C59H75Cl3N4O13
Density: 1.241±0.06 g/cm3
Description: It is a DCAF11-directed electrophilic PROTAC that can degrade multiple endogenous protein FBKP12 in human prostate cancer cells. DCAF11 is an E3 ligase that supports targeted protein degradation by electrophilic proteolysis-targeting chimera.
|
 |
BPL-201980 |
10-SLF |
2765058-89-5 |
DCAF11 |
FKBP12 |
Inquiry |
|
Molecular Weight: 1120.18
Molecular Formula: C59H76Cl2N4O13
Density: 1.219±0.06 g/cm3
Description: It is a DCAF11-directed electrophilic PROTAC that can degrade multiple endogenous protein FBKP12 in human prostate cancer cells. DCAF11 is an E3 ligase that supports targeted protein degradation by electrophilic proteolysis-targeting chimera.
|
 |
BPL-201981 |
21-ARL |
2765059-04-7 |
DCAF11 |
AR |
Inquiry |
|
Molecular Weight: 1027.87
Molecular Formula: C51H59Cl4N5O9
Boiling Point: 1112.9±65.0°C at 760 Torr
Density: 1.33±0.1 g/cm3
Description: It is a DCAF11-directed electrophilic PROTAC that can degrade multiple endogenous protein androgen receptor in human prostate cancer cells. DCAF11 is an E3 ligase that supports targeted protein degradation by electrophilic proteolysis-targeting chimera.
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![4-((5-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-5-oxopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione](https://resource.bocsci.com/structure/2732969-66-1.gif) |
BPL-201982 |
4-((5-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-5-oxopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
2732969-66-1 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 733.76
Molecular Formula: C38H36FN9O6
Density: 1.497±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![4-((6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-6-oxohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione](https://resource.bocsci.com/structure/2732969-67-2.gif) |
BPL-201983 |
4-((6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-6-oxohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
2732969-67-2 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 747.79
Molecular Formula: C39H38FN9O6
Density: 1.476±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![4-((7-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-7-oxoheptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione](https://resource.bocsci.com/structure/2732969-68-3.gif) |
BPL-201984 |
4-((7-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-7-oxoheptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
2732969-68-3 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 761.82
Molecular Formula: C40H40FN9O6
Density: 1.456±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![3-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide](https://resource.bocsci.com/structure/2732969-69-4.gif) |
BPL-201985 |
3-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide |
2732969-69-4 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 705.71
Molecular Formula: C36H32FN9O6
Density: 1.532±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![4-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)butanamide](https://resource.bocsci.com/structure/2732969-70-7.gif) |
BPL-201986 |
4-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)butanamide |
2732969-70-7 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 719.73
Molecular Formula: C37H34FN9O6
Density: 1.509±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![5-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pentanamide](https://resource.bocsci.com/structure/2732969-71-8.gif) |
BPL-201987 |
5-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pentanamide |
2732969-71-8 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 733.76
Molecular Formula: C38H36FN9O6
Density: 1.487±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide](https://resource.bocsci.com/structure/2732969-72-9.gif) |
BPL-201988 |
6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide |
2732969-72-9 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 747.79
Molecular Formula: C39H38FN9O6
Density: 1.466±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![7-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)heptanamide](https://resource.bocsci.com/structure/2732969-73-0.gif) |
BPL-201989 |
7-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)heptanamide |
2732969-73-0 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 761.82
Molecular Formula: C40H40FN9O6
Density: 1.447±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![8-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)octanamide](https://resource.bocsci.com/structure/2732969-74-1.gif) |
BPL-201990 |
8-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)octanamide |
2732969-74-1 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 775.84
Molecular Formula: C41H42FN9O6
Density: 1.429±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![5-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide](https://resource.bocsci.com/structure/2732969-75-2.gif) |
BPL-201991 |
5-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentanamide |
2732969-75-2 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 719.78
Molecular Formula: C38H38FN9O5
Density: 1.448±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
|
![6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide](https://resource.bocsci.com/structure/2732969-76-3.gif) |
BPL-201992 |
6-(4-(2-(4-Amino-5-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)-1H-benzo[d]imidazol-5-yl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide |
2732969-76-3 |
CRBN |
FLT3-ITD |
Inquiry |
|
Molecular Weight: 733.81
Molecular Formula: C39H40FN9O5
Density: 1.429±0.06 g/cm3
Description: It is a Dovitinib-modified PROTAC that enhances anti-proliferation effects against FLT3-ITD-positive acute myeloid leukemia cells. It can induce the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely block their downstream signaling pathway.
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