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E3 Ligase
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Structure Catalog Product Name CAS E3 Ligase Target Inquiry
8-(4-(4-(1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201933 8-(4-(4-(1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353495-40-4

CRBN

ALK

 Inquiry

Molecular Weight: 985.15

Molecular Formula: C54H64N8O10

Density: 1.38±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201934 8-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353495-42-6

CRBN

ALK

 Inquiry

Molecular Weight: 794.91

Molecular Formula: C45H46N8O6

Density: 1.46±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
(2S,4R)-1-((S)-2-(6-(4-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)piperazin-1-yl)-6-oxohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201935 (2S,4R)-1-((S)-2-(6-(4-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)piperazin-1-yl)-6-oxohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2353495-55-1

VHL

ALK

 Inquiry

Molecular Weight: 1022.33

Molecular Formula: C58H71N9O6S

Density: 1.33±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
(2S,4R)-1-((S)-2-(10-(4-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)piperazin-1-yl)-10-oxodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide BPL-201936 (2S,4R)-1-((S)-2-(10-(4-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)piperazin-1-yl)-10-oxodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2353493-33-9

VHL

ALK

 Inquiry

Molecular Weight: 1078.44

Molecular Formula: C62H79N9O6S

Density: 1.30±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(3-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanoyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201937 8-(4-(3-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanoyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353492-96-1

CRBN

ALK

 Inquiry

Molecular Weight: 813.91

Molecular Formula: C45H47N7O8

Boiling Point: 1071.5±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201938 8-(4-(1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2379864-82-9

CRBN

ALK

 Inquiry

Molecular Weight: 902.02

Molecular Formula: C49H55N7O10

Boiling Point: 1096.3±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanamide BPL-201939 N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-3-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanamide 2353492-97-2

CRBN

ALK

 Inquiry

Molecular Weight: 827.94

Molecular Formula: C46H49N7O8

Boiling Point: 1096.4±65.0°C at 760 Torr

Density: 1.41±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide BPL-201940 N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-amide 2353495-20-0

CRBN

ALK

 Inquiry

Molecular Weight: 916.05

Molecular Formula: C50H57N7O10

Boiling Point: 1120.0±65.0°C at 760 Torr

Density: 1.38±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201941 8-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2379672-57-6

CRBN

ALK

 Inquiry

Molecular Weight: 711.78

Molecular Formula: C40H37N7O6

Boiling Point: 1049.9±65.0°C at 760 Torr

Density: 1.49±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201942 8-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353493-05-5

CRBN

ALK

 Inquiry

Molecular Weight: 739.83

Molecular Formula: C42H41N7O6

Boiling Point: 1052.1±65.0°C at 760 Torr

Density: 1.45±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201943 8-(4-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353493-07-7

CRBN

ALK

 Inquiry

Molecular Weight: 767.89

Molecular Formula: C44H45N7O6

Boiling Point: 1055.8±65.0°C at 760 Torr

Density: 1.42±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide BPL-201944 N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide 2353495-22-2

CRBN

ALK

 Inquiry

Molecular Weight: 725.81

Molecular Formula: C41H39N7O6

Boiling Point: 1076.5±65.0°C at 760 Torr

Density: 1.47±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanamide BPL-201945 N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanamide 2353495-24-4

CRBN

ALK

 Inquiry

Molecular Weight: 753.86

Molecular Formula: C43H43N7O6

Boiling Point: 1078.1±65.0°C at 760 Torr

Density: 1.43±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanamide BPL-201946 N-(1-(3-Cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)piperidin-4-yl)-6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanamide 2353493-09-9

CRBN

ALK

 Inquiry

Molecular Weight: 781.91

Molecular Formula: C45H47N7O6

Boiling Point: 1081.3±65.0°C at 760 Torr

Density: 1.40±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201947 8-(4-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353495-44-8

CRBN

ALK

 Inquiry

Molecular Weight: 822.97

Molecular Formula: C47H50N8O6

Density: 1.42±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(4-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201948 8-(4-(4-(6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353493-11-3

CRBN

ALK

 Inquiry

Molecular Weight: 851.02

Molecular Formula: C49H54N8O6

Density: 1.40±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
SIAIS091 BPL-201949 SIAIS091 2570252-77-4

CRBN

ALK
ALK G1202R

 Inquiry

Molecular Weight: 780.93

Molecular Formula: C45H48N8O5

Density: 1.42±0.1 g/cm3

Description: SIAIS091 is an ALK degrader constructed from Alectinib. It can degrade ALK effectively at low nanomolar concentrations in cells, and its inhibitory effect on cell growth is obviously better than Alectinib. SIAIS091 promotes G1/S phase cell cycle arrest.
8-(4-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)butanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201950 8-(4-(4-(4-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)butanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2570252-78-5

CRBN

ALK

 Inquiry

Molecular Weight: 808.98

Molecular Formula: C47H52N8O5

Density: 1.39±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(4-(5-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)pentanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201951 8-(4-(4-(5-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)pentanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2570252-79-6

CRBN

ALK

 Inquiry

Molecular Weight: 823.01

Molecular Formula: C48H54N8O5

Density: 1.38±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.
8-(4-(4-(6-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile BPL-201952 8-(4-(4-(6-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 2353493-14-6

CRBN

ALK

 Inquiry

Molecular Weight: 837.04

Molecular Formula: C49H56N8O5

Density: 1.37±0.1 g/cm3

Description: It is a potent ALK degrader constructed from Alectinib.

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