| Structure |
Catalog |
Product Name |
CAS |
E3 Ligase |
Target |
Inquiry |
![8-(4-(4-(7-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)heptanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](https://resource.bocsci.com/structure/2570252-80-9.gif) |
BPL-201953 |
8-(4-(4-(7-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)heptanoyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile |
2570252-80-9 |
CRBN |
ALK |
Inquiry |
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Molecular Weight: 851.07
Molecular Formula: C50H58N8O5
Density: 1.35±0.1 g/cm3
Description: It is a potent ALK degrader constructed from Alectinib.
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 |
BPL-201954 |
SIAIS001 |
2570251-63-5 |
CRBN |
ALK
ALK G1202R |
Inquiry |
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Molecular Weight: 789.98
Molecular Formula: C48H51N7O4
Density: 1.37±0.1 g/cm3
Description: SIAIS001 is an orally bioavailable ALK degrader constructed from Alectinib. It can degrade ALK effectively at low nanomolar concentrations in cells, and its inhibitory effect on cell growth is obviously better than Alectinib. SIAIS001 promotes G1/S phase cell cycle arrest.
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![8-(4-(4-(6-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](https://resource.bocsci.com/structure/2570251-64-6.gif) |
BPL-201955 |
8-(4-(4-(6-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hex-5-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile |
2570251-64-6 |
CRBN |
ALK |
Inquiry |
|
Molecular Weight: 804.01
Molecular Formula: C49H53N7O4
Density: 1.36±0.1 g/cm3
Description: It is a potent ALK degrader constructed from Alectinib.
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![8-(4-(4-(7-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](https://resource.bocsci.com/structure/2570251-65-7.gif) |
BPL-201956 |
8-(4-(4-(7-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hept-6-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile |
2570251-65-7 |
CRBN |
ALK |
Inquiry |
|
Molecular Weight: 818.04
Molecular Formula: C50H55N7O4
Density: 1.34±0.1 g/cm3
Description: It is a potent ALK degrader constructed from Alectinib.
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![8-(4-(4-(8-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](https://resource.bocsci.com/structure/2570251-66-8.gif) |
BPL-201957 |
8-(4-(4-(8-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile |
2570251-66-8 |
CRBN |
ALK |
Inquiry |
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Molecular Weight: 832.06
Molecular Formula: C51H57N7O4
Density: 1.33±0.1 g/cm3
Description: It is a potent ALK degrader constructed from Alectinib.
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![8-(4-(4-(9-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)non-8-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](https://resource.bocsci.com/structure/2570251-67-9.gif) |
BPL-201958 |
8-(4-(4-(9-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)non-8-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile |
2570251-67-9 |
CRBN |
ALK |
Inquiry |
|
Molecular Weight: 846.09
Molecular Formula: C52H59N7O4
Density: 1.32±0.1 g/cm3
Description: It is a potent ALK degrader constructed from Alectinib.
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 |
BPL-201959 |
SIAIS121 |
2600730-81-0 |
CRBN |
EGFR e19d
EGFR L858R/T790M |
Inquiry |
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Molecular Weight: 798.23
Molecular Formula: C39H37ClFN9O7
Boiling Point: 1062.9±65.0°C at 760 Torr
Density: 1.489±0.06 g/cm3
Description: It is a CRBN-based PROTAC that effectively degrades EGFRL858R+ T790M mutant proteins through both proteosome and autophagy/lysosome degradation systems.
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 |
BPL-201960 |
SIAIS122 |
2600732-50-9 |
CRBN |
EGFR e19d
EGFR L858R/T790M |
Inquiry |
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Molecular Weight: 812.26
Molecular Formula: C40H39ClFN9O7
Boiling Point: 1067.5±65.0°C at 760 Torr
Density: 1.470±0.06 g/cm3
Description: It is a CRBN-based PROTAC that effectively degrades EGFRL858R+ T790M mutant proteins through both proteosome and autophagy/lysosome degradation systems.
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 |
BPL-201961 |
SIAIS123 |
2600732-51-0 |
CRBN |
EGFR e19d
EGFR L858R/T790M |
Inquiry |
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Molecular Weight: 826.29
Molecular Formula: C41H41ClFN9O7
Boiling Point: 1072.4±65.0°C at 760 Torr
Density: 1.452±0.06 g/cm3
Description: It is a CRBN-based PROTAC that effectively degrades EGFRL858R+ T790M mutant proteins through both proteosome and autophagy/lysosome degradation systems.
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 |
BPL-201962 |
SIAIS124 |
2600732-52-1 |
CRBN |
EGFR e19d
EGFR L858R/T790M |
Inquiry |
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Molecular Weight: 840.31
Molecular Formula: C42H43ClFN9O7
Boiling Point: 1076.4±65.0°C at 760 Torr
Density: 1.435±0.06 g/cm3
Description: It is a CRBN-based PROTAC that effectively degrades EGFRL858R+ T790M mutant proteins through both proteosome and autophagy/lysosome degradation systems.
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 |
BPL-201963 |
SIAIS125 |
2600730-82-1 |
CRBN |
EGFR e19d
EGFR L858R/T790M |
Inquiry |
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Molecular Weight: 854.34
Molecular Formula: C43H45ClFN9O7
Boiling Point: 1078.8±65.0°C at 760 Torr
Density: 1.419±0.06 g/cm3
Description: It is a CRBN-based PROTAC that effectively degrades EGFRL858R+ T790M mutant proteins through both proteosome and autophagy/lysosome degradation systems.
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 |
BPL-201964 |
SIAIS126 |
2600730-83-2 |
CRBN |
EGFR e19d
EGFR L858R/T790M |
Inquiry |
|
Molecular Weight: 868.37
Molecular Formula: C44H47ClFN9O7
Boiling Point: 1081.5±65.0°C at 760 Torr
Density: 1.404±0.06 g/cm3
Description: It is a CRBN-based PROTAC that effectively degrades EGFRL858R+ T790M mutant proteins through both proteosome and autophagy/lysosome degradation systems.
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![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)succinamide](https://resource.bocsci.com/structure/2639330-23-5.gif) |
BPL-201965 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)succinamide |
2639330-23-5 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 863.40
Molecular Formula: C40H47ClN10O8S
Boiling Point: 1150.1±65.0°C at 760 Torr
Density: 1.50±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
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![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)succinamide](https://resource.bocsci.com/structure/2639330-24-6.gif) |
BPL-201966 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)succinamide |
2639330-24-6 |
CRBN |
SHP2 |
Inquiry |
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Molecular Weight: 907.45
Molecular Formula: C42H51ClN10O9S
Boiling Point: 1164.3±65.0°C at 760 Torr
Density: 1.48±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
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![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)succinamide](https://resource.bocsci.com/structure/2639330-25-7.gif) |
BPL-201967 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)succinamide |
2639330-25-7 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 951.49
Molecular Formula: C44H55ClN10O10S
Boiling Point: 1179.2±65.0°C at 760 Torr
Density: 1.46±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
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 |
BPL-201968 |
ZB-S-29 |
2639330-26-8 |
CRBN |
SHP2 |
Inquiry |
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Molecular Weight: 979.56
Molecular Formula: C46H59ClN10O10S
Boiling Point: 1188.7±65.0°C at 760 Torr
Density: 1.43±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethyl)succinamide](https://resource.bocsci.com/structure/2639330-27-9.gif) |
BPL-201969 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethyl)succinamide |
2639330-27-9 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 863.38
Molecular Formula: C40H47ClN10O8S
Boiling Point: 1155.9±65.0°C at 760 Torr
Density: 1.50±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethyl)succinamide](https://resource.bocsci.com/structure/2639330-28-0.gif) |
BPL-201970 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethyl)succinamide |
2639330-28-0 |
CRBN |
SHP2 |
Inquiry |
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Molecular Weight: 907.44
Molecular Formula: C42H51ClN10O9S
Boiling Point: 1169.9±65.0°C at 760 Torr
Density: 1.48±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
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![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)succinamide](https://resource.bocsci.com/structure/2639330-29-1.gif) |
BPL-201971 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)succinamide |
2639330-29-1 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 951.49
Molecular Formula: C44H55ClN10O10S
Boiling Point: 1184.5±65.0°C at 760 Torr
Density: 1.46±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
|
![N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(3-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)propoxy)ethoxy)ethoxy)propyl)succinamide](https://resource.bocsci.com/structure/2639330-30-4.gif) |
BPL-201972 |
N1-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(3-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)propoxy)ethoxy)ethoxy)propyl)succinamide |
2639330-30-4 |
CRBN |
SHP2 |
Inquiry |
|
Molecular Weight: 979.54
Molecular Formula: C46H59ClN10O10S
Boiling Point: 1193.9±65.0°C at 760 Torr
Density: 1.43±0.1 g/cm3
Description: It is a thalidomide-based PROTAC small molecule as the highly efficient SHP2 degrader.
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