Name: PROTAC ERα Degrader-1
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Solubility

Soluble in DMSO (10 mM), Water (≥150 mg/mL)

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere

IUPACName

4-[(3S,4S)-7-cyano-1-[(2-methoxynaphthalen-1-yl)methyl]-4-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-2-oxo-3,4-dihydro-1,5-benzodiazepine-5-carbonyl]-N-[2-[2-[2-[2-[4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenoxy]ethyl-methylamino]-2-oxoethoxy]ethoxy]ethyl]benzamide

Synonyms

Benzamide, 4-[[(2S,3S)-8-cyano-2,3,4,5-tetrahydro-5-[(2-methoxy-1-naphthalenyl)methyl]-2-methyl-3-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-4-oxo-1H-1,5-benzodiazepin-1-yl]carbonyl]-N-[2-[2-[2-[[2-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-2-oxoethoxy]ethoxy]ethyl]-; 4-((2S,3S)-8-cyano-5-((2-methoxynaphthalen-1-yl)methyl)-2-methyl-3-((S)-2-(methylamino)propanamido)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-1-carbonyl)-N-(2-(2-(2-((2-(4-(1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)-2-oxoethoxy)ethoxy)ethyl)benzamide; 4-[[(2S,3S)-8-Cyano-2,3,4,5-tetrahydro-5-[(2-methoxy-1-naphthalenyl)methyl]-2-methyl-3-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-4-oxo-1H-1,5-benzodiazepin-1-yl]carbonyl]-N-[2-[2-[2-[[2-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-2-oxoethoxy]ethoxy]ethyl]benzamide

Boiling Point

1234.6±65.0°C at 760 Torr

Density

1.32±0.1 g/cm3

InChI Key

SNBOCOFSYPHJLP-KCRPDNSUSA-N

InChI

InChI=1S/C66H69N7O10/c1-7-54(46-13-9-8-10-14-46)61(48-22-27-52(74)28-23-48)49-24-29-53(30-25-49)83-36-34-71(5)60(75)42-82-38-37-81-35-33-69-64(77)50-18-20-51(21-19-50)65(78)73-44(3)62(70-63(76)43(2)68-4)66(79)72(57-31-17-45(40-67)39-58(57)73)41-56-55-16-12-11-15-47(55)26-32-59(56)80-6/h8-32,39,43-44,62,68,74H,7,33-38,41-42H2,1-6H3,(H,69,77)(H,70,76)/t43-,44-,62-/m0/s1

SMILES

N#CC1=CC=C2C(=C1)N(C(=O)C3=CC=C(C=C3)C(=O)NCCOCCOCC(=O)N(C)CCOC4=CC=C(C=C4)C(C5=CC=C(O)C=C5)=C(C=6C=CC=CC6)CC)C(C)C(NC(=O)C(NC)C)C(=O)N2CC7=C(OC)C=CC=8C=CC=CC87

Mechanism

Target: Targets estrogen receptor alpha (ERα) for experimental targeted protein degradation studies.

Binding Site: Binds the ERα ligand-binding domain and cereblon thalidomide-binding pocket to support productive ternary complex formation.

Mechanism of Action: PROTAC ERα Degrader-1 is designed for use in PROTAC or targeted protein degradation experiments directed toward estrogen receptor alpha (ERα). The bifunctional molecule links a target-recognition element to cereblon, promoting proximity between the protein of interest and ubiquitination machinery. Productive ternary-complex formation can drive polyubiquitination and proteasome-dependent target depletion, allowing researchers to compare pharmacological inhibition with protein removal. It is suitable for evaluating degradation potency, kinetics, pathway selectivity, and downstream signaling consequences in engineered or disease-relevant cellular models.

Applications

• PROTAC-Mediated ERα Degradation: This product is designed for research focused on the targeted degradation of estrogen receptor alpha (ERα). By utilizing the PROTAC mechanism, it facilitates the ubiquitination and subsequent proteasomal degradation of ERα, offering a powerful tool for dissecting estrogen receptor signaling pathways in various biological contexts.

• Targeted Protein Degradation Studies: PROTAC ERα Degrader-1 enables detailed exploration of protein degradation pathways, specifically targeting ERα. Researchers can employ this degrader to investigate the effects of selective ERα downregulation, providing insights into the role of ERα in cellular processes and disease models.

• Mechanistic Insights into PROTACs: This product serves as an exemplary model for studying the mechanistic aspects of PROTAC technology. By focusing on ERα, researchers can gain a deeper understanding of how PROTACs achieve selective protein degradation, contributing to the development of next-generation degraders in the field of targeted protein degradation.

• Functional Analysis of ERα Signaling: Utilizing PROTAC ERα Degrader-1 allows for precise manipulation of ERα levels in experimental systems. This approach enables the functional analysis of ERα-dependent signaling pathways, facilitating research into hormone-driven cancers and other ERα-related biological phenomena.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂