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3-Mercaptopropionic acid NHS ester - CAS 117235-10-6

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3-Mercaptopropionic acid NHS ester is a PROTAC linker, which is composed of alkyl chains. 3-Mercaptopropionic acid NHS ester can be used to synthesize a range of PROTACs.

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Molecular Formula

C₇H₉NO₄S

Molecular Weight

203.22

3-Mercaptopropionic acid NHS ester

- Specification
  - Solubility
    
    In DMSO: 100 mg/mL (492.08 mM; Need ultrasonic)
    
    Storage
    
    Pure form, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month
    
    Shipping
    
    Room temperature in continental US; may vary elsewhere.
    
    IUPAC Name
    
    (2,5-dioxopyrrolidin-1-yl) 3-sulfanylpropanoate
- Properties
  - InChI Key
    
    UTBOEPMMEANMPS-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C7H9NO4S/c9-5-1-2-6(10)8(5)12-7(11)3-4-13/h13H,1-4H2
    
    Canonical SMILES
    
    C1CC(=O)N(C1=O)OC(=O)CCS
- Reference Reading
  - 1. Self-assembled monolayers as the coating in a quartz piezoelectric crystal immunosensor to detect Salmonella in aqueous solution
    
    Y S Fung, Y Y Wong Anal Chem. 2001 Nov 1;73(21):5302-9. doi: 10.1021/ac010655y.
    
    A new procedure based on the self-assembled monolayers (SAM) of alkanethiols was developed to immobilize antibodies onto gold electrodes of a quartz crystal microbalance (QCM) for detecting Salmonella paratyphi A. The procedure includes (1) chemisorption of 3-mercaptopropionic acid (MPA) at electrode surfaces to produce a carboxylic acid terminated monolayer, (2) activation by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydrosuccinimide (NHS) to generate a stable acyl amino ester intermediate, and (3) condensation of antibodies after aminolysis of the NHS adduct. Activation by two coupling agents (EDC and NHS) was shown to enhance the stability of the coating and facilitate the formation of a suitable intermediate to condense antibodies reproducibly and densely at the SAM, leading to high sensitivity and good precision of the developed immunosensor. With 50 min incubation under continuous monitoring, working ranges from 10(2) to 10(5) cells/mL with repeatability < 10% RSD were obtained. On the basis of S/N = 3, the detection limit was 1.7 x 10(2) cells/mL The MO2 piezoimmunosensor developed was specific to differentiate S. paratyphi A against Escherichia coli and other serogroups of Salmonella that are commonly present together.
- Preparing Stock Solutions
  - ConcentrationVolumeMass 1 mg 5 mg 10 mg
    
    1 mM 4.9208 mL 24.6039 mL 49.2078 mL
    
    5 mM 0.9842 mL 4.9208 mL 9.8416 mL
    
    10 mM 0.4921 mL 2.4604 mL 4.9208 mL

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	4.9208 mL	24.6039 mL	49.2078 mL
5 mM	0.9842 mL	4.9208 mL	9.8416 mL
10 mM	0.4921 mL	2.4604 mL	4.9208 mL

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