Hydroxy-PEG4-acetic acid
CAS No.: 70678-95-4
Cat No.: BP-501384
Purity: >97%
4.5 
Hydroxy-PEG4-acetic acid is a PEG-based linker featuring a terminal hydroxyl group and a carboxylic acid at the opposite end, providing a short, flexible hydrophilic tether of approximately four ethylene glycol units. In PROTAC and targeted protein degradation designs, such PEG linkers are commonly used to modulate the spatial relationship between the ligand-binding “warhead” and the recruiting module, improving productive ternary complex formation by reducing steric clashes and increasing conformational freedom. The hydroxyl and carboxyl functionalities enable straightforward chemical conjugation strategies, including esterification or amide coupling to attach the linker to functional handles on other PROTAC components, while the PEG segment enhances aqueous solubility and can reduce nonspecific interactions. This linker value lies in its ability to tune linker length and polarity to optimize degradation potency and selectivity during systematic structure–activity studies, supporting reproducible synthesis of modular PROTAC constructs for mechanistic and cellular evaluation.
Structure of 70678-95-4
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Hydroxy-PEG4-acetic acid is a polyethylene glycol-based linker building block designed to support the synthesis and optimization of PROTACs and related targeted protein degradation constructs. Its hydrophilic PEG segment can enhance solubility and help tune linker flexibility and spatial presentation between binding elements. The terminal hydroxyl and carboxylic acid functionality enable versatile conjugation strategies commonly used in linker assembly. Detailed structural and reactivity considerations are provided below.
Structure: The molecule comprises a PEG chain bearing a terminal hydroxyl group and a terminal acetic acid functionality. It contains repeating ether linkages that confer flexibility and strong hydrogen-bonding capability, alongside a carboxylic acid for further derivatization. Overall, it is a polar, water-compatible linker.
Reactivity: The carboxylic acid can be activated for amide or ester coupling using standard peptide-coupling approaches, enabling attachment to amine- or alcohol-containing partners under mild conditions. The terminal hydroxyl supports formation of ether or ester linkages via appropriate electrophiles or activated derivatives. Typical PROTAC linker assembly relies on preserving PEG integrity by using compatible solvents and avoiding harsh, strongly dehydrating conditions that could degrade sensitive intermediates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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