AcS-PEG6-OH
CAS No.: 1352221-63-6
Cat No.: BP-500759
Purity: ≥95%
4.5 
AcS-PEG6-OH is an acylthio-activated polyethylene glycol linker featuring a six-unit PEG chain terminated with a hydroxyl group. The “AcS” functionality provides a chemically addressable thioester/acetylthio handle that can be used to couple the linker to thiol-containing ligands, enabling controlled formation of conjugates while preserving the solubility and conformational flexibility imparted by the PEG segment. In PROTAC and targeted protein degradation workflows, PEG-based linkers are widely used to tune the effective distance and relative orientation between the two binding domains (e.g., a target-recruiting ligand and an E3 ligase ligand), thereby influencing ternary complex stability and degradation potency. This product is valuable for researchers seeking modular, water-compatible linker chemistry to assemble PROTACs or related bifunctional degraders, and for optimizing linker length and attachment chemistry during iterative structure–activity studies.
Structure of 1352221-63-6
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* For research and manufacturing use only. Not for human or clinical use.
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AcS-PEG6-OH is a PEG-based linker designed to support efficient PROTAC assembly by providing a hydrophilic, flexible spacer that can improve solubility and help tune the spatial relationship between a ligand and an E3-recruiting warhead. Its ether-rich PEG scaffold is well suited for attaching to functional groups through standard linker-conjugation chemistries, enabling robust synthesis workflows for targeted protein degradation studies. The detailed structural and reactivity characteristics are provided below.
Structure: AcS-PEG6-OH contains a poly(ethylene glycol) chain terminated with a hydroxyl group and an AcS-derived handle, featuring repeating ether linkages that confer high polarity and conformational flexibility. The molecule includes stable C–O and C–C bonds typical of PEG scaffolds, supporting favorable solvation and reduced aggregation.
Reactivity: The hydroxyl terminus enables ether or ester formation under common coupling conditions using activated carbonyl derivatives or halide/mesylate-type activation strategies, while the AcS-derived functionality supports conjugation approaches consistent with thioester/thioether chemistry used in linker elaboration. Typical PROTAC linker construction employs nucleophilic substitution or acylation steps in polar aprotic or alcohol-containing solvents, often using base and standard coupling reagents to drive clean formation of the desired linkage.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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