mPEG5-alcohol
CAS No.: 23778-52-1
Cat No.: BP-500676
Purity: >98%
4.5 
mPEG5-alcohol is a methoxy-poly(ethylene glycol) alcohol with a short PEG chain, terminating in a primary hydroxyl group that enables straightforward chemical handling and conjugation chemistry. Structurally, it provides a flexible, hydrophilic PEG spacer that can improve solubility and reduce nonspecific interactions of PROTAC-related intermediates or conjugates, while the terminal alcohol serves as a reactive handle for forming linkages to other functional moieties (e.g., via esterification or ether/urethane-forming routes depending on the coupling strategy). In targeted protein degradation workflows, such PEG spacers are commonly used to tune linker length, polarity, and accessibility of the recruiter and ligand domains, thereby influencing ternary complex formation and degradation efficiency. As a practical building block, mPEG5-alcohol supports the preparation of PROTACs and related degraders where controlled hydrophilicity and modular attachment points are critical for reproducible synthesis and subsequent biochemical evaluation.
Structure of 23778-52-1
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mPEG5-alcohol is an mPEG-based linker building block designed for constructing PROTACs and related targeted protein degradation conjugates where controlled hydrophilicity and steric tuning are beneficial. Its ether-rich polyethylene glycol scaffold supports solubility and can help mitigate nonspecific interactions, improving the practical handling of conjugates. The following sections describe its structure and the typical reactivity considerations relevant to PROTAC assembly.
Structure: The linker consists of an mPEG chain terminated by a primary alcohol, featuring repeating ether linkages along the polyethylene glycol backbone. This structure provides a flexible, highly solvated, and chemically stable polyether framework with a terminal hydroxyl suitable for functional group interconversion.
Reactivity: The terminal alcohol enables standard PEG functionalization routes used in PROTAC synthesis, including conversion to activated derivatives (for example, via esterification or carbonate/halide-type activation) followed by nucleophilic coupling to amine- or hydroxyl-bearing partners. Typical conditions employ compatible organic solvents and mild bases or coupling reagents, with reaction design guided by preserving sensitive ligands and minimizing hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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