Amino-PEG10-alcohol

Amino-PEG10-alcohol, provides a hydrophilic, flexible polyethylene glycol (PEG) spacer terminating in a primary amino group and a hydroxyl handle. Such dual functionality enables modular conjugation to targeting ligands and E3-recruiting moieties, supporting efficient assembly of degraders with improved solubility and reduced nonspecific interactions. The detailed structural and reactivity characteristics are provided below.

Structure: Amino-PEG10-alcohol is a PEG-based linker featuring repeating ether units that confer conformational flexibility, along with a terminal primary amino group and an alcohol. Its structure contains ether linkages and aliphatic C–N and C–O bonds, typically yielding a water-compatible, polar, and hydrogen-bonding capable scaffold.

Reactivity: The terminal amino group is suited for nucleophilic acyl substitution or coupling reactions to install activated carboxylates or carboxylic acid derivatives, while the alcohol can participate in esterification or ether-forming transformations under standard organic synthesis conditions. Common approaches include amide or carbamate bond formation using coupling reagents, with polar aprotic solvents and mild bases to preserve PEG integrity. Reaction design should consider PEG’s solubility and steric accessibility to maintain efficient conjugation.