Name: Amino-PEG12-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine

Synonyms

H2N-PEG12-CH2CH2NH2; 1,38-Diamino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane; 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaoctatriacontane-1,38-diamine

Boiling Point

621.3±50.0°C at 760 mmHg

Density

1.087±0.06 g/cm3 at 20°C, 760 Torr

InChI Key

LBBOTXXNKBSUJN-UHFFFAOYSA-N

InChI

InChI=1S/C26H56N2O12/c27-1-3-29-5-7-31-9-11-33-13-15-35-17-19-37-21-23-39-25-26-40-24-22-38-20-18-36-16-14-34-12-10-32-8-6-30-4-2-28/h1-28H2

SMILES

C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN)N

This Amino-PEG12-amine linker is designed for flexible, water-compatible conjugation in PROTAC architectures, enabling efficient spatial tuning between a ligand-recruiting moiety and an E3 ligase binder. Its poly(ethylene glycol) character supports solubility and reduces nonspecific interactions, while the terminal amines provide versatile handles for covalent assembly. The subsequent points describe the structural features and practical reactivity considerations for constructing PROTACs using this linker.

Structure: Amino-PEG12-amine is a linear poly(ethylene glycol) chain terminated by primary amine groups. The backbone consists of repeating ether linkages, providing conformational flexibility and hydrophilicity. Terminal C–N bonds enable formation of stable amide or urea linkages through nucleophilic acyl substitution or related coupling chemistry.

Reactivity: The two primary amines are suitable for PROTAC linker installation via amide coupling with activated carboxylic acids (for example, using carbodiimide-based systems) or via isocyanate/activated carbonate chemistry to form urea or related conjugates. Reactions are typically performed under anhydrous or controlled-moisture conditions with appropriate base and compatible solvents such as polar aprotic media, while maintaining pH ranges that preserve amine nucleophilicity.

Stock concentration: *

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂