NX-2127

 CAS No.: 2416131-46-7  Cat No.: BP-300201  Purity: 98% by HPLC 4.5  

NX-2127 is an oral, first-in-class small molecule degrader of BTK. It drives targeted BTK and IKZF3 degradation through ubiquitination and proteasomal degradation.

NX-2127

Structure of 2416131-46-7

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Ligand for Target Protein
Molecular Formula
C39H45N9O5
Molecular Weight
719.8
Appearance
Light Yellow to Yellow Solid

* For research and manufacturing use only. Not for human or clinical use.

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Purity
98% by HPLC
Appearance
Light Yellow to Yellow Solid
IUPACName
3-[4-[1-[[(3S)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]pyrrolidin-3-yl]methyl]piperidin-4-yl]anilino]-5-piperidin-1-ylpyrazine-2-carboxamide
Synonyms
NX 2127; NX2127
InChI Key
XLWJWCMQMBVNSG-ACXKHFGCSA-N
InChI
InChI=1S/C39H45N9O5/c40-35(50)34-36(43-32(21-41-34)46-15-2-1-3-16-46)42-27-6-4-25(5-7-27)26-13-17-45(18-14-26)22-24-12-19-47(23-24)28-8-9-29-30(20-28)39(53)48(38(29)52)31-10-11-33(49)44-37(31)51/h4-9,20-21,24,26,31H,1-3,10-19,22-23H2,(H2,40,50)(H,42,43)(H,44,49,51)/t24-,31?/m0/s1
Canonical SMILES
C1CCN(CC1)C2=CN=C(C(=N2)NC3=CC=C(C=C3)C4CCN(CC4)CC5CCN(C5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C(=O)N

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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