Amino-PEG24-alcohol
CAS No.: 2226726-55-0
Cat No.: BP-501068
4.5 
Amino-PEG24-alcohol is a heterobifunctional PEG-based linker featuring a terminal primary amine and a terminal hydroxyl group separated by a long, flexible poly(ethylene glycol) chain. The extended PEG length and ether-rich backbone provide strong aqueous solubility, conformational flexibility, and reduced nonspecific hydrophobic interactions, while the two reactive termini enable straightforward conjugation chemistry. In PROTAC and targeted protein degradation workflows, this linker is used to spatially tune the relative positioning of a ligand-binding module (e.g., E3 ligase binder or target binder) and to promote productive ternary complex formation by allowing the connected moieties to sample favorable orientations. The hydroxyl/amine functionality supports common coupling strategies such as amide formation or controlled functional group derivatization prior to final assembly. As a research tool, Amino-PEG24-alcohol helps optimize linker length and hydrophilicity, improving construct stability and experimental tractability during iterative PROTAC design and evaluation.
Structure of 2226726-55-0
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Amino-PEG24-alcohol is a polyethylene glycol–based linker designed for assembling PROTACs that require flexible spacing between a targeting ligand and an E3 ligase binder. Its PEG-rich backbone promotes favorable solubility and conformational adaptability, which can improve productive ternary complex formation. The molecule also provides a functional handle for conjugation chemistry, supporting robust synthetic workflows. Detailed structural and reactivity considerations are provided below.
Structure: Amino-PEG24-alcohol consists of a PEG chain terminating in a primary alcohol and an amino functionality, enabling bifunctional conjugation. The linker features ether linkages along the PEG backbone and a terminal hydroxyl group, offering hydrophilicity and conformational flexibility relevant to PROTAC architectures.
Reactivity: The primary alcohol and amino group support standard PROTAC-compatible coupling strategies, including esterification or ether formation from the alcohol and amide or carbamate formation from the amino group. Typical approaches use activated carboxylic acid derivatives or coupling reagents under mild base or neutral conditions, often in polar organic solvents, with careful control of moisture to limit side reactions. Mechanistically, nucleophilic substitution and acyl-transfer steps enable stable covalent attachment to ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
