m-PEG7-COOH
CAS No.: 874208-91-0
Cat No.: BP-501073
Purity: >98%
4.5 
m-PEG7-COOH is a monofunctional methoxy-terminated polyethylene glycol linker bearing a terminal carboxylic acid, providing a flexible, hydrophilic spacer with an approximately seven-ethylene-glycol repeat unit chain. The PEG backbone confers conformational freedom and improves aqueous solubility while reducing nonspecific hydrophobic interactions, and the carboxylate enables straightforward conjugation to PROTAC components through standard amide coupling or related carboxyl-reactive chemistries. In PROTAC design, this type of linker is used to tune the effective distance and relative orientation between the ligand “warhead” that binds the target protein and the E3-ligase recruiter, thereby facilitating productive ternary complex formation and efficient ubiquitination. As a research tool, m-PEG7-COOH supports systematic linker optimization, helping investigators balance degradation potency with favorable pharmacokinetic-like properties such as reduced aggregation and improved handling during synthesis and assay workflows.
Structure of 874208-91-0
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This m-PEG7-COOH linker is a polyethylene glycol-based carboxylic acid designed for modular PROTAC assembly, enabling efficient conjugation between a targeting ligand and an E3 ligase binder. Its flexible PEG scaffold improves solubility and can help mitigate steric constraints that may otherwise impair ternary complex formation. The following sections describe its structure and the practical reactivity considerations for constructing PROTACs using this linker.
Structure: m-PEG7-COOH contains a methoxy-terminated PEG chain bearing a carboxylic acid at the opposite terminus. The linker features ether linkages along the PEG backbone, providing conformational flexibility. The terminal acid enables formation of stable amide or ester derivatives, while the PEG segment confers hydrophilicity and favorable dispersion in polar media.
Reactivity: The carboxylic acid functionality is typically converted to activated intermediates (such as acid chlorides or activated esters) under standard peptide-coupling or acylation conditions. Coupling to amine-bearing ligands proceeds via nucleophilic acyl substitution, often using coupling reagents and bases in compatible polar solvents. Reaction design generally emphasizes mild temperatures, controlled pH, and exclusion of moisture to preserve linker integrity and maintain functional group compatibility during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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