Aminooxy-PEG12-amido-PEG12-(mPEG11)3
Cat No.: BP-502175
Purity: >90%
4.5 
Aminooxy-PEG12-amido-PEG12-(mPEG11)3 is a heterobifunctional, multi-arm polyethylene glycol (PEG) linker designed for PROTAC and targeted protein degradation constructs. Structurally, it combines an aminooxy reactive handle with a PEG-based, extended and flexible spacer architecture featuring amide linkages and a tri-methyl ether capped PEG segment, providing a defined, long-range separation between conjugated partners while maintaining aqueous solubility. In PROTAC design, the aminooxy group enables chemoselective conjugation to aldehyde-functionalized ligands or other carbonyl-containing moieties, allowing researchers to connect the “warhead” and the E3 ligase-recruiting element through a stable oxime-forming linkage strategy. The PEG spacer and branched mPEG region help reduce steric interference, improve effective reach and local concentration at the target interface, and can modulate physicochemical properties relevant to synthesis and handling. This linker is therefore valuable for building modular, well-defined degradation molecules and for optimizing linker length and geometry during experimental screening.
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* For research and manufacturing use only. Not for human or clinical use.
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Aminooxy-PEG12-amido-PEG12-(mPEG11)3 is a polyethylene glycol (PEG)-based, aminooxy-functional linker designed to support modular PROTAC assembly and controlled conjugation chemistry. Its combination of an aminooxy handle with amide-linked PEG segments enables robust attachment to targeting ligands while maintaining solubility and conformational flexibility typical of effective PROTAC linkers. The subsequent points provide detailed descriptions of its structure and practical reactivity considerations for researchers.
Structure: The linker contains an aminooxy functional group and multiple PEG segments connected through amide linkages, with terminal methoxy-PEG character. It features ether-rich, flexible chain segments that promote hydrophilicity and reduce aggregation, while the amide bonds provide chemical stability under typical coupling conditions.
Reactivity: The aminooxy group is suitable for oxime-forming conjugation with aldehyde-functional partners, enabling chemoselective linker installation under mild conditions. PROTAC construction commonly uses aldehyde–aminooxy coupling to generate stable oxime linkages, followed by standard peptide/amide coupling strategies for amide formation when required. Reactions are typically performed in aqueous or mixed aqueous/organic solvents using buffering to maintain functional-group compatibility; catalysts are generally selected based on aldehyde reactivity and oxime formation requirements.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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