Aminooxy-PEG7-Aminooxy
CAS No.: 1383980-52-6
Cat No.: BP-500489
Purity: ≥95%
4.5 
Aminooxy-PEG7-Aminooxy is a bifunctional, linear polyethylene glycol (PEG) linker bearing two terminal aminooxy groups, enabling chemoselective oxime ligation with aldehyde-containing partners. The PEG7 chain provides a flexible, hydrophilic spacer that reduces steric interference and can improve solubility and effective reach between the two conjugation sites in multicomponent constructs. In PROTAC design, this linker can be used to connect or functionalize ligands that have been equipped with aldehydes, allowing formation of stable oxime linkages under mild conditions, thereby creating a defined tether between the target-binding module and the E3 ligase-recruiting moiety. Its dual reactive handles make it suitable for iterative assembly of targeted degradation agents and for systematic structure–activity studies in which linker length and attachment chemistry are varied. Overall, it is a practical reagent for constructing well-defined PROTAC architectures that support reproducible synthesis and downstream biochemical evaluation.
Structure of 1383980-52-6
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This Aminooxy-PEG7-Aminooxy linker is designed for building PROTAC conjugates that require efficient, modular attachment points to targeting ligands. Its bifunctional aminooxy termini enable chemoselective oxime ligation strategies, supporting stable linker–ligand assembly under mild conditions. The flexible PEG-based scaffold can help tune solubility and spatial presentation of functional groups, which is often beneficial for targeted protein degradation workflows. Detailed structural and reactivity considerations are provided below.
Structure: The molecule is a PEG-based flexible chain bearing two aminooxy functional groups at opposite ends. It contains ether linkages characteristic of poly(ethylene glycol) segments, providing conformational flexibility and enhanced hydrophilicity. The aminooxy groups are heteroatom-rich, supporting selective condensation chemistry with carbonyl partners.
Reactivity: Aminooxy termini participate in oxime formation with aldehydes or ketones via chemoselective condensation, typically promoted by mildly acidic conditions to drive dehydration. For PROTAC assembly, one can generate oxime-linked intermediates between each aminooxy end and appropriately functionalized ligand fragments. Reactions are commonly performed in aqueous or mixed aqueous/organic solvents, with careful control of pH and stoichiometry to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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