ANB-NOS
CAS No.: 60117-35-3
Cat No.: BP-500986
Purity: 95%
4.5 
ANB-NOS is a PROTAC linker building block featuring an anilide-based nitrogen-containing scaffold with a nitroso-oxidation-state motif (NOS) that can serve as a chemically addressable handle for constructing bifunctional degraders. Structurally, it provides a defined, relatively rigid connection element that can transmit conformational constraints between the ligand-binding “warhead” and the E3 ligase–recruiting moiety, while the amide linkage supports productive geometry and hydrogen-bonding interactions that often influence ternary complex formation. In PROTAC design, such linkers are selected to balance distance, flexibility, and orientation so that the recruited E3 ligase and target protein can engage simultaneously, promoting ubiquitination and subsequent proteasomal degradation. As a modular intermediate, ANB-NOS is valuable for researchers optimizing linker length and attachment chemistry, enabling systematic structure–activity relationship studies to improve degradation potency and selectivity in targeted protein degradation workflows.
Structure of 60117-35-3
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ANB-NOS is a photoactivatable heterobifunctional linker for PROTAC-related probe and conjugate construction. It combines an amine-reactive NHS ester with a nitrophenyl azide group, allowing staged covalent attachment followed by light-triggered crosslinking. The structural and reactivity features are described below.
Structure: The linker contains an N-hydroxysuccinimide ester and a nitrophenyl azide aromatic group. The activated ester supports acyl transfer to amines, while the aryl azide provides a photoreactive handle.
Reactivity: The NHS ester reacts with primary amines to form amide bonds under mild, amine-compatible conditions. After initial conjugation, the nitrophenyl azide can be activated by light to generate a reactive nitrene that inserts into nearby bonds or captures adjacent groups. This makes ANB-NOS useful for PROTAC probe mapping and proximity-labeling designs.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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