Azido-PEG7-CH2COOH
CAS No.: 1446411-32-0
Cat No.: BP-500932
Purity: ≥95%
4.5 
Azido-PEG7-CH2COOH is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide for bioorthogonal conjugation and a carboxymethyl group for attachment to PROTAC warheads or other functional moieties. The PEG chain provides a flexible, hydrophilic spacer that helps minimize steric interference and can improve effective reach between the binding domains of a PROTAC, thereby supporting productive formation of the ternary complex. In targeted protein degradation workflows, the azide handle enables copper-catalyzed or strain-promoted azide–alkyne cycloaddition to install the linker onto an alkyne-bearing ligand, while the carboxyl group supports amide coupling to introduce the linker into the overall PROTAC architecture. This linker is valuable for assembling modular degradation constructs, facilitating structure–activity optimization by varying conjugation chemistry and spatial presentation without altering the core binding ligands.
Structure of 1446411-32-0
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG7-CH2COOH, is designed to provide a flexible polyethylene glycol (PEG) spacer that enhances solubility and spatial reach between an E3 ligase ligand and a target-binding moiety. Its terminal azide enables bioorthogonal conjugation strategies, while the carboxylic acid offers a reliable handle for amide-bond formation. These features make it well suited for assembling targeted protein degradation constructs, with the detailed structural and synthetic considerations provided below.
Structure: The linker contains an azide functional group at one terminus, a PEG-based polyether chain for conformational flexibility, and a terminal carboxylic acid for acyl coupling. It features ether linkages along the PEG backbone, an aliphatic methylene spacer, and an azide-bearing carbon, enabling stable covalent conjugation.
Reactivity: The azide group can participate in copper-catalyzed azide–alkyne cycloaddition or related azide-compatible click chemistries to connect to alkyne-bearing partners under mild, aqueous-compatible conditions. The carboxylic acid supports amide-bond formation via standard coupling chemistries using activated carboxyl intermediates, typically employing coupling reagents and base in polar organic or mixed solvents. Mechanistically, conjugation proceeds through azide–alkyne bond formation or acyl substitution to yield robust linkages.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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