BCN-POE3-amine
CAS No.: 1263166-93-3
Cat No.: BP-501582
Purity: >99%
4.5 
BCN-POE3-amine is a bicyclononyne (BCN)–functionalized poly(ethylene glycol) linker bearing a terminal primary amine, designed for copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) conjugation in targeted protein degradation workflows. Structurally, it comprises a BCN cyclooctyne-like reactive handle connected through a short, flexible ethylene glycol chain of three repeat units to an amine terminus, providing both aqueous compatibility and a convenient site for subsequent coupling to degraders, ligands, or linker fragments. In PROTAC construction, the BCN moiety enables rapid, bioorthogonal attachment to azide-bearing components, allowing assembly of multicomponent systems without metal catalysts that can interfere with sensitive reagents or biological assays. The terminal amine further supports derivatization (e.g., amide or urea formation) to tune linker length, polarity, and spatial presentation. This reagent is valuable for researchers seeking modular, efficient conjugation strategies to generate and optimize PROTACs and related targeted degradation probes.
Structure of 1263166-93-3
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
BCN-POE3-amine is a BCN-based, amine-terminated polyethylene glycol linker designed for efficient incorporation into PROTAC architectures. Its cyclooctyne motif supports bioorthogonal conjugation, while the flexible POE segment helps tune linker length, solubility, and conformational freedom between the target-binding ligand and the recruited E3 ligase module. This product is particularly useful for constructing degraders where robust, selective coupling chemistry and favorable physicochemical properties are required; detailed structural and reactivity considerations are provided below.
Structure: BCN-POE3-amine contains a bicyclononyne (BCN) reactive cyclooctyne core connected to a polyethylene oxide (POE) chain terminating in a primary amine. The molecule features an amine-bearing linker with ether-rich segments, enabling hydrogen bonding and improved aqueous compatibility.
Reactivity: BCN-POE3-amine is suited for strain-promoted azide–alkyne cycloaddition (SPAAC) with azide-functional partners under mild, catalyst-free conditions. For PROTAC assembly, the amine handle can be used for standard amide or urea-forming coupling strategies with activated carboxylic acid derivatives. Typical workflows employ aqueous or mixed aqueous/organic solvents and rely on maintaining azide and BCN integrity, avoiding strongly nucleophilic or reducing conditions that could compromise functional groups.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
