Benzenedimethanamine-diethylamine
CAS No.: 71277-17-3
Cat No.: BP-500868
Purity: 97%
4.5 
Benzenedimethanamine-diethylamine is a bifunctional, amine-containing linker building block featuring a benzene core substituted with two methanamine arms and terminal diethylamine groups. Structurally, it provides flexible attachment points through secondary/tertiary amine functionalities, enabling chemists to connect or tune the spatial relationship between a targeting ligand and an E3-recruiting moiety in PROTAC constructs. In targeted protein degradation designs, such linkers are used to control linker length, conformational mobility, and the effective presentation of the two binding elements to promote formation of a productive ternary complex. By offering adaptable amine chemistry for coupling strategies (e.g., reductive amination, amide/urea formation after appropriate functional-group conversion, or salt formation to adjust solubility), this scaffold can support systematic structure–activity relationship studies. Its value lies in facilitating rational linker optimization to improve degradation potency and selectivity while maintaining synthetic modularity for iterative PROTAC synthesis.
Structure of 71277-17-3
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Benzenedimethanamine-diethylamine, is a versatile amine-bearing building block commonly used to connect or functionalize PROTAC components through robust amide or urea-forming coupling strategies. Its bifunctional amine character supports modular synthesis of targeted protein degraders, enabling researchers to tune linker length, polarity, and attachment chemistry for efficient ternary-complex formation.
Structure: The molecule contains a benzenedimethanamine core bearing two amine substituents, enabling multiple sites for nucleophilic derivatization. It features aromatic carbon–carbon bonds alongside benzylic carbon–nitrogen bonds, with basic amine functionalities that can be protonated under mildly acidic conditions.
Reactivity: Suitable PROTAC assembly typically relies on amine-directed coupling reactions, such as forming amides or related linkages from carboxylic acids or activated ester derivatives. Common approaches use carbodiimide or uronium-type activation, often with base-promoted conditions, in polar aprotic solvents. Mechanistically, nucleophilic attack by the linker amine on an activated carbonyl intermediate yields the desired conjugate, with purification by standard chromatographic methods to remove excess reagents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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