Name: Benzyl-PEG9-THP
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]oxane

Synonyms

2-[(1-Phenyl-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl)oxy]tetrahydro-2H-pyran; 2H-Pyran, tetrahydro-2-[(28-phenyl-3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl)oxy]-; Tetrahydro-2-[(28-phenyl-3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl)oxy]-2H-pyran

Boiling Point

631.6±55.0°C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

UPOGSHHHOLZUFV-UHFFFAOYSA-N

InChI

InChI=1S/C30H52O11/c1-2-6-29(7-3-1)28-39-25-24-37-21-20-35-17-16-33-13-12-31-10-11-32-14-15-34-18-19-36-22-23-38-26-27-41-30-8-4-5-9-40-30/h1-3,6-7,30H,4-5,8-28H2

SMILES

C1CCOC(C1)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCC2=CC=CC=C2

Benzyl-PEG9-THP is a polyethylene glycol-based PROTAC linker designed to connect a benzyl handle to a THP (tetrahydropyran) protected functional group through a PEG spacer. Its flexible, hydrophilic architecture supports productive ternary complex formation and improves solubility and handling of conjugates. This linker is well suited for assembling targeted protein degradation constructs, and the following points describe its structure and practical reactivity considerations in PROTAC synthesis.

Structure: The molecule contains a benzyl moiety linked to a PEG chain and a THP-protected group, featuring ether linkages within the PEG backbone and an acetal-type THP functionality. Overall, it is characterized by conformational flexibility, high polarity, and solubility-enhancing ether-rich composition.

Reactivity: THP-protected functionalities are typically introduced or carried through synthesis and then deprotected under mild acidic conditions to reveal a reactive alcohol or related nucleophile for subsequent coupling. For PROTAC assembly, the liberated group can be used in standard esterification or ether-forming reactions with activated carboxylic acid derivatives or electrophiles. Commonly used conditions employ acid catalysts in suitable polar solvents, followed by purification to remove byproducts.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂