Biotin-PEG3-oxyamine
CAS No.: 1786206-22-1
Cat No.: BP-501334
4.5 
Biotin-PEG3-oxyamine is a PEG-based linker bearing a biotin affinity handle and a terminal oxyamine functional group, providing a flexible, hydrophilic spacer between conjugated partners. The short PEG3 chain confers aqueous solubility and reduces steric interference, while the biotin moiety enables strong, high-affinity capture on streptavidin or related binding proteins for purification, immobilization, or assay readouts. The oxyamine terminus is designed for chemoselective coupling to carbonyl-containing groups (for example, aldehydes or activated ketones) to form stable oxime or related linkages, allowing controlled attachment of the linker to PROTAC components or other molecular scaffolds. In targeted protein degradation workflows, this linker is valuable for constructing degraders with modular attachment points, facilitating characterization of ternary complex formation, and supporting pull-down experiments that verify recruitment and engagement of the target protein.
Structure of 1786206-22-1
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Biotin-PEG3-oxyamine is a bifunctional PEG-based linker designed to support targeted protein degradation workflows by enabling robust conjugation between biotin-tagging handles and amine-reactive partners used in PROTAC architectures. Its polyethylene glycol segment provides conformational flexibility and improved aqueous compatibility, while the terminal oxyamine functionality supports chemoselective coupling strategies. This product is well suited for researchers assembling PROTACs or related degraders where stable, well-defined linker geometry and efficient bioconjugation are required; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a biotin moiety connected through a flexible polyethylene glycol chain to an oxyamine terminus. It contains ether linkages within the PEG segment and an oxime/oxyamine-derived functional group capable of forming stable conjugates. Overall, it is an amphiphilic, water-compatible scaffold with conformational mobility.
Reactivity: The oxyamine functionality is typically employed for amide or oxime-related conjugation routes with complementary electrophiles bearing activated carbonyls or appropriate aldehyde/ketone partners, following established bioconjugation principles. Coupling is commonly performed under mild aqueous or mixed-solvent conditions using standard peptide-coupling reagents or aldehyde/ketone-compatible chemistries, with pH control to maintain functional-group reactivity. Reaction progress is generally monitored by analytical methods such as LC-MS or HPLC, and purification is performed to remove unreacted starting materials.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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