Biotin-PEG4-alcohol
CAS No.: 1217609-84-1
Cat No.: BP-500925
Purity: >97%
4.5 
Biotin-PEG4-alcohol is a biotin-functionalized polyethylene glycol linker featuring a four–ethylene glycol unit spacer terminated with a primary alcohol. The PEG segment provides a flexible, hydrophilic, and protease-resistant distance between the biotin moiety and the point of attachment, which helps minimize steric interference when conjugated to larger ligands or biomolecules. In PROTAC and targeted degradation research, such biotin–PEG linkers are commonly used as modular handles to enable affinity capture, immobilization, or detection of PROTAC constructs via high-affinity biotin–streptavidin interactions. The linker’s spacing can improve accessibility of the biotin for binding while maintaining solubility and reducing nonspecific adsorption. This product is valuable for workflows that require robust tethering of degraders to streptavidin-coated surfaces, beads, or assay formats, facilitating mechanistic studies, pull-down experiments, and quantitative characterization of targeted protein degradation reagents.
Structure of 1217609-84-1
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Biotin-PEG4-alcohol is a PEG-based linker designed to support PROTAC construction by providing a hydrophilic, conformationally flexible spacer between a biotin-derived recognition element and a protein-binding or conjugation handle. Its ether-rich poly(ethylene glycol) character can help tune solubility and reduce steric interference, which is beneficial for efficient ternary complex formation in targeted protein degradation workflows. The
Structure: The molecule contains a biotin-derived moiety connected through a poly(ethylene glycol) spacer to a terminal alcohol. Its ether linkages and flexible ethylene glycol units confer high polarity and conformational adaptability, while the terminal hydroxyl enables straightforward functional-group interconversion for PROTAC assembly.
Reactivity: The terminal alcohol supports common PROTAC linker chemistry, including conversion to activated esters or carbonates for amide or carbamate bond formation with nucleophilic partners. Typical approaches use coupling reagents (for example, carbodiimides for ester-to-amide strategies) under mild base conditions, with polar aprotic solvents such as DMF or DMSO to promote efficient coupling while preserving sensitive functional groups.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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