Biotin-PEG9-CH2CH2COOH
Cat No.: BP-502043
4.5 
Biotin-PEG9-CH2CH2COOH is a biotin-functionalized polyethylene glycol linker featuring an extended PEG chain (nine ethylene glycol units) terminated with a carboxylic acid, providing both a hydrophilic spacer and a chemically addressable handle for amide or ester coupling. In PROTAC and targeted degradation workflows, the biotin moiety enables orthogonal conjugation or affinity-based capture, for example to immobilize PROTACs on streptavidin-coated supports for controlled assembly, purification, or assay readouts, while the PEG spacer helps reduce steric interference between the ligand-binding domains of the degrader. The terminal carboxyl group supports attachment to other reactive components (such as activated esters or amine-containing ligands), facilitating modular construction of bifunctional degraders or related linker intermediates. This product is valuable for researchers seeking reproducible, water-soluble linker architectures that improve conjugation flexibility and support downstream biochemical characterization of targeted protein degradation systems.
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* For research and manufacturing use only. Not for human or clinical use.
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Biotin-PEG9-CH2CH2COOH is a polyethylene glycol-based PROTAC linker designed to connect biotin-tagged recognition elements with carboxyl-functional handles for efficient conjugation. Its PEG-rich, flexible scaffold can improve solubility and conformational adaptability, which are often beneficial for targeted protein degradation workflows. The carboxylic acid functionality enables straightforward coupling to amine- or hydrazide-bearing ligands, supporting modular PROTAC assembly. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a biotin moiety tethered through a PEG chain to a terminal ethyl spacer bearing a carboxylic acid. It contains ether linkages within the PEG segment, amide/ester-compatible functional groups at the terminus, and a flexible, hydrophilic backbone that promotes aqueous compatibility.
Reactivity: The terminal carboxylic acid is suitable for standard PROTAC linker formation via amide coupling using carbodiimide-based activation with coupling additives, typically in polar aprotic solvents under controlled pH. Alternatively, it can be converted to activated esters or used in coupling chemistries that proceed through formation of an acyl intermediate. Reaction success is commonly improved by minimizing hydrolysis and using freshly prepared activators.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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