Biotin-PEG7-thiourea
CAS No.: 2353409-59-1
Cat No.: BP-501573
4.5 
Biotin-PEG7-thiourea is a heterobifunctional PROTAC linker featuring a biotin handle connected through a polyethylene glycol spacer of intermediate length to a thiourea motif. Structurally, the biotin moiety provides a strong affinity tag for streptavidin or avidin-based capture, while the PEG segment imparts aqueous solubility and conformational flexibility that can reduce steric interference between the two ends of a conjugate. The thiourea group serves as a functional linker element capable of engaging in targeted chemistry at the PROTAC assembly stage, enabling controlled connection to electrophilic or complementary reactive partners used to build degraders. In targeted protein degradation workflows, this design is particularly valuable for studying ternary complex formation and for enabling pull-down or enrichment of PROTAC conjugates from biological matrices. The linker’s combination of affinity capture and spacer-mediated flexibility supports robust experimental handling, improved conjugate recovery, and more reliable downstream analysis of degradation-related interactions.
Structure of 2353409-59-1
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Biotin-PEG7-thiourea is a PEG-based linker designed to connect a biotin targeting handle with a thiourea functional group commonly used in PROTAC assembly strategies. Its flexible polyethylene glycol segment can enhance solubility and conformational adaptability, while the thiourea motif provides a versatile attachment point for coupling to protein-binding ligands. This product supports modular synthesis of targeted protein degraders, and the following sections describe its structure and practical reactivity considerations in PROTAC workflows.
Structure: The linker comprises a biotin moiety linked through a polyethylene glycol chain to a thiourea group. It contains ether linkages within the PEG segment and a thiourea core featuring C–S and C–N bonds, providing a polar, hydrogen-bonding-capable scaffold that supports aqueous compatibility.
Reactivity: The thiourea functionality is typically employed in coupling schemes that form stable linkages to PROTAC ligand components under nucleophilic substitution or thiourea-derivatization conditions. Suitable approaches often use activating reagents compatible with thiourea chemistry, with polar aprotic solvents to maintain solubility and reaction efficiency. Mild temperatures and careful pH control are generally used to preserve functional-group integrity and minimize side reactions during stepwise assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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