Thalidomide-linker 1

 Cat No.: BP-100056  Purity: ≥98% 4.5  

Thalidomide-linker 1 is a crosslinker−E3 ligase ligand conjugate composed of a cereblon-recuiting ligand thalidomide and a PEGylated crosslinker. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Thalidomide-linker 1

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Category
E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C23H30N4O9.HCl
Molecular Weight
542.97

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥98%
ShelfLife
2 years
Storage
-20°C
Synonyms
N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
InChI Key
ORRMBTUTYKQYQU-UHFFFAOYSA-N
InChI
InChI=1S/C23H30N4O9.ClH/c24-6-8-33-10-12-35-13-11-34-9-7-25-19(29)14-36-17-3-1-2-15-20(17)23(32)27(22(15)31)16-4-5-18(28)26-21(16)30;/h1-3,16H,4-14,24H2,(H,25,29)(H,26,28,30);1H
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCN.Cl

Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

Calculate
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g
Historical Records: Biotin-PEG3-NHS ester | SR-1114 | Pomalidomide-C6-CO2H | Pomalidomide-C3-CO2H | Pomalidomide-C9-CO2H | Pomalidomide-PEG6-CO2H | Pomalidomide-PEG6-Alkyne | CCT367766 formic | Thalidomide-linker 2 | Pomalidomide-PEG3-azide | Thalidomide-linker 1

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