(+)-Biotin-SLC
CAS No.: 1864003-57-5
Cat No.: BP-501075
4.5 
(+)-Biotin-SLC is a stereodefined biotin-containing PROTAC linker designed to connect a biotin/avidin-binding module to a second targeted-recognition or effector moiety through a short, chemically stable linker (“SLC”) architecture. Structurally, it incorporates the high-affinity biotin motif while providing a functional handle for conjugation, enabling controlled spatial presentation of the second ligand and improving the probability of productive ternary-complex formation. In PROTAC workflows, the biotin element can be used to recruit or anchor the construct to avidin or streptavidin-fusion partners, thereby facilitating proximity-driven engagement of the target protein when the other end carries an appropriate recruiting ligand or degradation-driving element. This product is valuable for researchers developing modular, avidin/streptavidin-mediated targeted degradation systems, where reliable bioconjugation chemistry and defined linker geometry are critical for tuning cooperativity, cellular uptake, and degradation efficiency.
Structure of 1864003-57-5
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* For research and manufacturing use only. Not for human or clinical use.
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(+)-Biotin-SLC is a biotin-based PROTAC linker designed to enable targeted protein degradation by connecting a biotin recognition element to a recruiting ligand through a stable, functionalized spacer. Its features support modular assembly of bifunctional degraders, facilitating systematic optimization of linker length, polarity, and attachment chemistry to tune ternary complex formation. The detailed structural and synthetic considerations for using this linker in PROTAC workflows are provided below.
Structure: The linker incorporates a biotin-derived scaffold with an amide-containing connectivity that supports robust conjugation chemistry. It contains heteroatoms that can engage in hydrogen bonding and modulate local polarity, while the carbonyl and amide functionalities provide chemical stability under typical bioconjugation conditions.
Reactivity: This linker is suitable for PROTAC construction via covalent coupling strategies that form stable amide or related linkages between the linker and protein-ligand moieties. Practical assembly typically relies on activation of a carboxyl or amine handle, followed by nucleophilic substitution under mild, anhydrous conditions using standard coupling reagents and compatible bases. Reaction monitoring by chromatographic or spectroscopic methods is recommended to confirm completion and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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