Diketone-PEG12-Biotin
Cat No.: BP-501820
4.5 
Diketone-PEG12-Biotin is a heterobifunctional PROTAC linker featuring a PEG-based hydrophilic chain of defined length, terminated with a biotin moiety and containing a diketone handle that supports stable conjugation chemistry. Structurally, the linker provides a flexible, water-soluble spacer that reduces steric interference between the two functional ends, while the diketone functionality enables robust attachment to carbonyl-reactive or metal-mediated coupling partners used in targeted degradation constructs. In PROTAC design, this scaffold can be used to position a biotin-tagged recognition element for affinity-based capture or to tether the PROTAC to biotin-binding components, thereby facilitating controlled assembly, purification, or cellular delivery strategies. Its PEG architecture improves aqueous handling and can enhance the productive engagement of the degrader and target-binding ligands by maintaining favorable relative geometry. Overall, Diketone-PEG12-Biotin is valuable for researchers developing modular targeted protein degradation workflows that require reliable, conjugation-compatible linkers and affinity-enabled experimental control.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Diketone-PEG12-Biotin is a polyethylene glycol (PEG)-based linker engineered for modular construction of PROTACs, combining a biotin handle with a diketone-containing connectivity motif. Its flexible, hydrophilic PEG segment supports favorable linker solvation and conformational adaptability, while the diketone functionality enables reliable attachment strategies to assemble ternary-complex degraders. The biotin moiety further facilitates orthogonal conjugation and analytical workflows. The following points describe the linker’s structure and practical reactivity for PROTAC synthesis in detail below.
Structure: The linker comprises a PEG chain bearing a biotin group and a diketone-containing linkage region. It features ether linkages within the PEG backbone, carbonyl groups characteristic of diketones, and amide/heteroatom-rich motifs typical of biotin derivatives. Overall polarity and hydrogen-bonding capacity promote solubility and reduced aggregation.
Reactivity: Suitable PROTAC assembly typically relies on functional-group pairing at the linker termini, using diketone-associated chemistry for controlled conjugation to warheads or E3 ligase-binding units. Reaction design generally follows carbonyl-reactive coupling principles, with conditions chosen to preserve PEG integrity and avoid side reactions such as over-oxidation or uncontrolled condensation. Mild bases or coupling reagents compatible with PEG and biotin are commonly selected, using polar aprotic solvents and inert atmosphere when required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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