Bis-PEG10-acid
CAS No.: 2055023-26-0
Cat No.: BP-501480
Purity: ≥95%
4.5 
Bis-PEG10-acid is a bifunctional polyethylene glycol (PEG) linker bearing two terminal carboxylic acid groups, providing a flexible, hydrophilic spacer for constructing PROTACs and other targeted protein degradation conjugates. Structurally, it consists of two PEG chains of defined length connected through the “bis” architecture, with carboxylate handles that can be activated (e.g., via standard coupling chemistries) to form stable amide or ester linkages to ligands on either side of a degrader. In PROTAC design, this type of linker helps tune the effective distance and relative orientation between an E3 ligase-recruiting moiety and the target-binding ligand, thereby improving the probability of productive ternary complex formation while reducing nonspecific hydrophobic interactions through PEG-mediated solvation. Its value for targeted degradation research lies in enabling systematic linker optimization, supporting aqueous solubility, and offering a straightforward modular platform for synthesizing degraders for in vitro evaluation of potency and selectivity.
Structure of 2055023-26-0
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Bis-PEG10-acid is a polyethylene glycol (PEG)-based bifunctional linker designed for constructing PROTACs that require controlled spatial separation between a target-binding ligand and an E3 ligase recruiter. Its hydrophilic, flexible architecture can support favorable solubility and conformational adaptability, which are often important for efficient ternary complex formation. The subsequent points provide detailed descriptions of the linker’s structure and practical reactivity considerations for PROTAC synthesis.
Structure: The linker comprises a PEG backbone bearing two terminal carboxylic acid functionalities, connected through ether linkages typical of PEG. This combination yields a flexible, water-compatible scaffold with multiple hydrogen-bonding sites. The carboxyl groups enable stable amide or ester formation under standard coupling chemistries.
Reactivity: The terminal carboxylic acids are suitable for activation and subsequent coupling to amine- or hydrazide-functional groups on PROTAC partners. Typical approaches include carboxyl activation using carbodiimide-based reagents with an auxiliary coupling additive, or conversion to reactive acid derivatives followed by nucleophilic acyl substitution. Mild, anhydrous organic solvents and controlled pH are commonly used to minimize side reactions, while preserving linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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