Bis-PEG7-t-butyl ester
Cat No.: BP-501870
4.5 
Bis-PEG7-t-butyl ester is a bifunctional polyethylene glycol (PEG) linker bearing two PEG7 arms terminated as tert-butyl ester groups, providing a flexible, water-compatible spacer with two protected carboxylate handles. In PROTAC design, such bis-PEG linkers are used to tune the spatial relationship between the two ligands that recruit an E3 ligase and the target protein, thereby optimizing ternary complex formation and degradation efficiency. The PEG backbone increases solubility and reduces nonspecific aggregation, while the ester termini can be converted under appropriate conditions to carboxylates for subsequent amide-bond coupling to ligand scaffolds or other reactive intermediates. This linker format is particularly valuable for constructing modular, symmetrical conjugates where controlled linker length and dual attachment points are required to systematically evaluate how linker geometry impacts targeted protein degradation.
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* For research and manufacturing use only. Not for human or clinical use.
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Bis-PEG7-t-butyl ester is a PEG-based, bis-functional linker designed to enable modular construction of PROTACs and other targeted protein degradation conjugates. Its polyethylene glycol framework provides conformational flexibility and aqueous compatibility, while the t-butyl ester groups offer controlled chemical handles for downstream coupling strategies. This product supports reliable assembly of bifunctional degraders by facilitating attachment between ligand moieties under broadly used ester-forming and ester-activation workflows. Detailed structural and reactivity considerations are provided below.
Structure: The molecule contains a bis-PEG7 scaffold bearing two t-butyl ester termini. It features ester linkages connecting PEG chains to tert-butyl-derived carbonyl groups, providing polarity and hydrogen-bonding capacity from the ether-rich PEG backbone. The flexible ether segments promote solvent exposure and linker mobility.
Reactivity: The t-butyl ester groups are typically employed as protected carboxyl equivalents that can be converted to reactive carboxylic acid forms under acid-mediated deprotection conditions. Subsequent coupling to amine- or hydrazide-bearing partners is commonly performed via standard carbodiimide-mediated ester/amide formation or related activation chemistries, using polar aprotic solvents and appropriate bases. Mechanistically, deprotection generates nucleophilic carboxylates, enabling controlled bond formation to build PROTAC linkages.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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