Azido-PEG36-alcohol
Cat No.: BP-501839
Purity: >95%
4.5 
Azido-PEG36-alcohol is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a hydroxyl-terminated PEG chain of extended length. Structurally, it provides a flexible, hydrophilic spacer that can be readily functionalized: the azide handle enables bioorthogonal conjugation via copper-free azide–alkyne cycloaddition (strain-promoted) to attach PROTAC warheads or ligands bearing a complementary alkyne, while the terminal alcohol offers an additional site for derivatization to introduce further coupling chemistry. In PROTAC design, such PEG linkers are widely used to tune the effective distance and relative orientation between the target-binding moiety and the E3 ligase ligand, often improving productive ternary complex formation and reducing steric clashes. This reagent is valuable for constructing modular targeted protein degraders, enabling systematic linker-length screening and efficient, chemoselective assembly under conditions compatible with sensitive ligands.
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG36-alcohol is a polyethylene glycol–based PROTAC linker bearing a terminal azide handle, designed to enable efficient conjugation of ligands through bioorthogonal click chemistry. Its PEG-rich scaffold provides conformational flexibility and improved solubility, which can enhance the effective reach between the target-binding and E3-recruiting modules. The azide functionality supports modular assembly of targeted protein degraders, and the detailed structure and reactivity considerations are provided below.
Structure: The linker consists of a PEG ether chain terminating in an azide group and a primary alcohol. It contains repeating ethylene glycol units connected by ether bonds, with the azide providing a reactive functional group for cycloaddition chemistry. The flexible, hydrophilic backbone supports favorable solvation and reduced steric constraints.
Reactivity: The terminal azide is well suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling modular PROTAC construction with alkyne-bearing ligand fragments. Typical conjugation workflows use appropriate Cu(I) sources and ligands for CuAAC, or copper-free conditions for SPAAC to minimize metal exposure. Solvent systems are commonly chosen to maintain solubility of PEG linkers and partners, while reaction monitoring ensures complete consumption of azide functionality before downstream purification.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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