Biotin-PEG4-PC-PEG4-alkyne
Cat No.: BP-501852
4.5 
Biotin-PEG4-PC-PEG4-alkyne is a heterobifunctional, PEG-based PROTAC linker featuring a biotin handle for high-affinity streptavidin capture, two short polyethylene glycol segments to provide aqueous solubility and conformational flexibility, a central proline-rich/PC-type spacer region for controlled distance and presentation, and a terminal alkyne for chemoselective conjugation. In targeted protein degradation workflows, such linkers are used to connect or functionalize degraders and auxiliary modules, enabling efficient assembly of multi-component constructs while minimizing steric interference at the binding interfaces. The PEG spacers help maintain productive geometry between the recruited ligand and the degradation machinery, whereas the alkyne allows attachment via copper-free or copper-catalyzed click-type strategies to generate defined conjugates. This product is valuable for researchers engineering PROTACs, biotinylated control reagents, and affinity-enrichment compatible degradation assays, supporting reproducible synthesis and downstream pull-down analyses of ternary complex formation.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Popular Publications Citing BOC Sciences Products
Biotin-PEG4-PC-PEG4-alkyne is a bifunctional, PEG-based PROTAC linker designed to connect a biotin-derived targeting handle to an alkyne-functional conjugation site while incorporating a central propargyl-compatible carbonyl motif. Its flexible polyethylene glycol segments enhance solubility and conformational adaptability, supporting productive ternary complex formation in targeted protein degradation workflows. The subsequent points describe the linker’s structural features and practical considerations for PROTAC construction using this chemistry.
Structure: The linker contains two PEG spacer domains flanking a central carbonyl-containing segment and terminates in a terminal alkyne for modular coupling. Its architecture is dominated by ether linkages and amide-like connectivity, providing conformational flexibility, polar surface character, and improved aqueous compatibility typical of PEGylated linkers.
Reactivity: The terminal alkyne enables copper-catalyzed azide–alkyne cycloaddition or related alkyne click strategies to assemble PROTACs from azide-bearing partners under standard inert or controlled-air conditions. Coupling is typically performed using Cu(I) sources with appropriate ligands, in polar organic/aqueous solvent mixtures, to promote efficient conjugation while minimizing side reactions. The PEG-rich environment supports solubility during synthesis and subsequent handling of intermediates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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