Name: Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>98.0%

Solubility

10 mm in DMSO

ShelfLife

0-4°C for short term (days to weeks), or -20°C for long term (months).

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Shipping

-20°C (International: -20°C)

IUPACName

InChI Key

JYTHRLPETJLRBH-SRSCFSCASA-N

InChI

InChI=1S/C66H99N13O17/c1-47(2)58(62(84)73-53(16-12-25-70-63(67)85)61(83)72-50-20-18-48(19-21-50)46-95-65(87)77(7)29-27-68-6)74-56(81)24-32-89-36-40-93-44-43-92-39-35-88-31-23-55(80)69-26-22-57(82)78-45-49-13-8-9-14-51(49)59-60(52-15-10-11-17-54(52)78)79(76-75-59)30-34-91-38-42-94-41-37-90-33-28-71-64(86)96-66(3,4)5/h8-11,13-15,17-21,47,53,58,68H,12,16,22-46H2,1-7H3,(H,69,80)(H,71,86)(H,72,83)(H,73,84)(H,74,81)(H3,67,70,85)/t53-,58-/m0/s1

SMILES

CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)N(C)CCNC)NC(=O)CCOCCOCCOCCOCCC(=O)NCCC(=O)N2CC3=CC=CC=C3C4=C(C5=CC=CC=C52)N(N=N4)CCOCCOCCOCCNC(=O)OC(C)(C)C

This PROTAC linker reagent is designed to enable efficient, modular assembly of targeted protein degraders by combining a PEG-based solubilizing scaffold with bioorthogonal click handles and a cleavable/functionalized connection motif. Its architecture supports flexible conjugation, improved aqueous compatibility, and reliable coupling strategies commonly used to generate PROTACs with defined stoichiometry and tunable linker length. Detailed structural and synthetic guidance is provided below.

Structure: The molecule contains PEG ether segments that confer hydrophilicity and conformational flexibility, alongside a triazole linkage and a DBCO cyclooctyne moiety for strain-promoted azide–alkyne cycloaddition. It also includes Boc-protected amine functionality and additional amide/ester-forming elements that support stable conjugation chemistry.

Reactivity: Use the DBCO group for strain-promoted click reactions with azide-bearing partners under mild, catalyst-free conditions in compatible aqueous or mixed-solvent systems. Subsequent PROTAC construction can incorporate amide-forming coupling to connect functional warhead/ligand fragments, while Boc deprotection is typically employed to reveal reactive amines for controlled conjugation. Solvent choice and pH should be optimized to preserve azide stability and maintain linker integrity.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂