BrCH2CONH-PEG3-acid

 CAS No.: 1807534-79-7  Cat No.: BP-501032  Purity: ≥95% 4.5  

BrCH2CONH-PEG3-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

BrCH2CONH-PEG3-acid

Structure of 1807534-79-7

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PROTAC Linker
Molecular Formula
C11H20BrNO6
Molecular Weight
342.19
Appearance
Pale Yellow or Colorless Oily Matter

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
Appearance
Pale Yellow or Colorless Oily Matter
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
3-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms
Bromoacetamido-PEG3-C2-acid; Bromoacetamido-PEG3-CH2CH2COOH; Bromoacetamido-PEG3-acid; 1-bromo-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oic acid; Propanoic acid, 3-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]-; 6,9,12-Trioxa-3-azapentadecan-15-oic acid, 1-bromo-2-oxo-; 3-(2-{2-[2-(2-bromoacetamido)ethoxy]ethoxy}ethoxy)propanoic acid
Boiling Point
524.3±50.0°C at 760 mmHg
Density
1.4±0.1 g/cm3
InChI Key
NZRUJYJTSFKZEG-UHFFFAOYSA-N
InChI
InChI=1S/C11H20BrNO6/c12-9-10(14)13-2-4-18-6-8-19-7-5-17-3-1-11(15)16/h1-9H2,(H,13,14)(H,15,16)
Canonical SMILES
C(COCCOCCOCCNC(=O)CBr)C(=O)O

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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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