BSJ-4-116

Name: BSJ-4-116
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 2519823-34-6

Cat No.: BP-400168 4.5

BSJ-4-116 is a PROTAC linked to ligands for Cereblon and CDK. It's a potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes by prematurely terminating transcription, particularly by increasing poly(adenylation). It exhibits strong antiproliferative effects, both alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib.

Structure of 2519823-34-6

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Category

PROTAC

Molecular Formula

C40H49ClN8O8S

Molecular Weight

837.38

Appearance

Solid

* For research and manufacturing use only. Not for human or clinical use.

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Solubility

DMSO: 250 mg/mL (298.55 mM; Need ultrasonic)

Appearance

Solid

Storage

Store at -20°C

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂