Cbz-N-amido-PEG2-acid
CAS No.: 1347750-76-8
Cat No.: BP-501574
Purity: >98%
4.5 
Cbz-N-amido-PEG2-acid is a polyethylene glycol–based linker building block featuring a Cbz-protected amide terminus and a terminal carboxylic acid, enabling robust conjugation chemistry in PROTAC synthesis. Structurally, it provides a short, flexible PEG spacer that can be incorporated between a ligand-bearing amine and a carboxyl-activated partner, or used to form amide/ester linkages that connect the targeting moiety to the E3 ligase–recruiting component. The PEG2 segment helps modulate the effective distance and conformational freedom between binding domains, which can improve productive ternary complex formation while reducing steric clashes that often limit targeted protein degradation efficiency. In targeted degradation research, this linker is valuable for systematic optimization of linker length and polarity, facilitating structure–activity relationship studies and improving synthetic accessibility for assembling modular PROTAC architectures.
Structure of 1347750-76-8
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Cbz-N-amido-PEG2-acid can be used as a polyethylene glycol spacer with a protected amino group and a terminal carboxylic acid for modular conjugation workflows. Its Cbz-protected amino, acid-terminated architecture enables straightforward conjugation strategies commonly used in targeted protein degradation workflows. The linker’s flexible, hydrophilic character can improve solubility and reduce steric constraints, and the subsequent sections below describe its structure and practical reactivity considerations in detail.
Structure: The linker features a PEG-based flexible spacer with a terminal carboxylic acid and a Cbz-protected amino group. It contains PEG ether connectivity and an aromatic Cbz carbamate, providing a balanced combination of polarity, hydrogen-bonding capacity, and conformational mobility.
Reactivity: The carboxylic acid enables coupling to amine-containing partners via standard amide-forming chemistries, typically using carbodiimide-based coupling systems with appropriate bases in polar aprotic solvents. The Cbz-protected nitrogen can be selectively deprotected under hydrogenolysis conditions to reveal a reactive amine for subsequent conjugation. Mechanistically, activation of the acid followed by nucleophilic acyl substitution forms the key amide bond used to assemble PROTAC constructs.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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