Cbz-N-amido-PEG5-acid
CAS No.: 1347750-74-6
Cat No.: BP-500953
Purity: >98%
4.5 
Cbz-N-amido-PEG5-acid is a protected, activated polyethylene glycol linker designed for constructing PROTACs and other targeted protein conjugates. Structurally, it contains a Cbz (benzyloxycarbonyl) carbamate-protecting group on the nitrogen, an amide linkage, and a PEG chain of intermediate length terminating in a carboxylic acid, providing both solubility and a defined attachment handle. In PROTAC architectures, the PEG spacer helps decouple the pharmacophores spatially, improving productive formation of the ternary complex by reducing steric clashes and modulating effective local concentrations near the recruited E3 ligase and target-binding ligands. The carboxylic acid functionality enables straightforward coupling to complementary amine-bearing fragments (e.g., via standard amide-forming chemistries), while the protected nitrogen supports controlled stepwise synthesis. This linker is valuable for researchers seeking reproducible linker length and polarity to tune degradation potency and selectivity in targeted protein degradation studies.
Structure of 1347750-74-6
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* For research and manufacturing use only. Not for human or clinical use.
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Cbz-N-amido-PEG5-acid is a polyethylene glycol-based PROTAC linker building block designed to provide a flexible, hydrophilic spacer between targeting and recruiting elements. Its ether-rich chain and terminal carboxylic acid support efficient conjugation strategies that preserve conformational freedom and improve solubility in typical PROTAC workflows. The subsequent points describe its structural features and practical reactivity considerations for constructing targeted protein degraders.
Structure: The linker contains a PEG oligomer segment with repeating ether linkages, a terminal carboxylic acid, and an amide functionality. A benzyloxycarbonyl (Cbz) protecting group is present, providing stability under mild conditions while enabling controlled deprotection or coupling. Overall, it combines flexibility, polarity, and reactive handles for bioconjugation.
Reactivity: The terminal carboxylic acid enables standard amide-forming coupling to amine-bearing ligands using carboxyl-activation chemistries such as carbodiimide/auxiliary reagents or activated ester approaches. The amide linkage formation proceeds via nucleophilic acyl substitution after activation. Typical conditions use polar aprotic or mixed solvent systems with base to maintain carboxyl activation, while the Cbz group can be retained or selectively removed depending on the coupling sequence and chosen conditions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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