Cbz-NH-PEG36-C2-acid
Cat No.: BP-502118
4.5 
Cbz-NH-PEG36-C2-acid is a PEG-based PROTAC linker featuring a Cbz-protected amide terminus connected to a long, flexible poly(ethylene glycol) chain and capped with a carboxylic acid at the opposite end. The extended PEG36 segment provides conformational mobility and aqueous solubility, while the terminal acid enables robust coupling to complementary functional groups on either the targeting ligand or the E3 ligase–binding moiety through standard amide- or ester-forming chemistries. In targeted protein degradation constructs, such linkers help position the two binding elements at an appropriate spatial distance and orientation to promote productive ternary complex formation, thereby improving the likelihood of ubiquitination and subsequent proteasomal degradation. As a modular building block, this compound is valuable for researchers optimizing linker length and polarity to tune degradation potency, selectivity, and physicochemical properties during PROTAC synthesis and structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This PEG-based PROTAC linker, Cbz-NH-PEG36-C2-acid (also referred to as Cbz-NH-PEG36-C2-carboxylic acid), is designed to provide a flexible, hydrophilic spacer between a ligand-binding element and an E3-recruiting module. Its ether-rich backbone supports favorable solubility and conformational adaptability, which can improve effective ternary complex formation and targeted protein degradation performance. The detailed structural and synthetic considerations for constructing PROTAC conjugates are provided below.
Structure: The linker contains a carbamate-protected amine (Cbz) connected to a long poly(ethylene glycol) chain, terminating in a carboxylic acid. It features ether linkages along the PEG segment, a carbamate carbonyl, and a terminal acid functionality. These groups confer high polarity, strong hydrogen-bonding capacity, and robust chemical stability under typical peptide-conjugation conditions.
Reactivity: The terminal carboxylic acid enables standard PROTAC coupling strategies to form stable amide or related linkages with complementary amine-bearing ligands. Common approaches use carboxyl-activation reagents (e.g., carbodiimides or uronium-type activators) in polar aprotic solvents, often with base to promote nucleophilic acyl substitution. The Cbz group can be removed under hydrogenolysis to reveal an amine for subsequent coupling steps, supporting modular assembly of bifunctional degraders.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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