Name: DBCO-NH-PEG4-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

10 mm in DMSO

Appearance

Light yellow oil

Application

Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

ShelfLife

0-4°C for short term (days to weeks), or -20°C for long term (months).

Storage

Store at -5°C,keep in dry and avoid sunlight.

Shipping

Room temperature, or blue ice upon request.

IUPACName

3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide

Synonyms

DBCO-PEG4-NH2;DBCO-NHCO-PEG4-amine TFA salt;DBCO-PEG4-amine;Azadibenzocyclooctyne-PEG4 amine; DBCO-PEG4 amine

Boiling Point

784.1±60.0 °C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

KTIOBJVNCOFWCL-UHFFFAOYSA-N

InChI

InChI=1S/C29H37N3O6/c30-13-16-36-18-20-38-22-21-37-19-17-35-15-12-28(33)31-14-11-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23,30H2,(H,31,33)

SMILES

C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCOCCOCCOCCOCCN

This DBCO-NH-PEG4-amine linker is designed for modular construction of PROTACs and related targeted protein degradation conjugates by enabling efficient, chemoselective attachment to biomolecules. Its DBCO handle supports rapid strain-promoted azide–alkyne cycloaddition, while the PEG-based chain provides solubility and conformational flexibility that can improve conjugation performance and linker presentation. Detailed structural and reactivity considerations are provided below.

Structure: The linker contains a dibenzocyclooctyne (DBCO) moiety connected through an amide to a polyethylene glycol (PEG) segment terminating in a primary amine. It features an alkynyl cyclooctyne for SPAAC and amide and ether linkages that confer hydrophilicity, flexibility, and stable covalent connectivity for PROTAC assembly.

Reactivity: The DBCO group reacts with azide-functional partners via strain-promoted azide–alkyne cycloaddition under catalyst-free conditions, typically in aqueous-compatible buffers. The terminal amine enables standard amide- or urea-forming coupling strategies with activated carboxylic acids or isocyanates, allowing installation of the linker into PROTAC architectures. Use of mild, non-nucleophilic conditions helps preserve azide/alkyne reactivity and minimize side reactions.

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂