DBCO-NHCO-PEG3-Fmoc
Cat No.: BP-502053
4.5 
DBCO-NHCO-PEG3-Fmoc is a heterobifunctional PROTAC linker featuring a cyclooctyne (DBCO) for strain-promoted azide–alkyne cycloaddition, a short polyethylene glycol spacer that provides aqueous compatibility and conformational flexibility, and an Fmoc-protected amide handle for controlled solid-phase or stepwise amide coupling. The NHCO segment connects the PEG chain to the reactive DBCO/amide framework, while the Fmoc group enables orthogonal functionalization under standard peptide chemistry conditions, allowing researchers to incorporate this linker into larger conjugates with defined attachment points. In PROTAC and targeted protein degradation workflows, the DBCO moiety enables rapid, bioorthogonal conjugation to azide-bearing ligands or payloads without requiring copper catalysis, facilitating assembly of multi-component degraders. The PEG3 spacer can help reduce steric hindrance and improve effective proximity between binding modules, supporting efficient formation of ternary complexes. This linker is valuable for constructing modular, site-selective PROTAC architectures for structure–activity and degradation mechanism studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This DBCO-NHCO-PEG3-Fmoc linker is designed for modular PROTAC assembly, combining a strained cyclooctyne handle for bioorthogonal conjugation with a PEG-based spacer that supports solubility and productive ternary complex formation. The Fmoc-protected carbamate enables controlled coupling strategies during linker or ligand preparation. Its orthogonal reactivity and flexible architecture make it advantageous for constructing targeted protein degraders, and the following sections describe its structure and practical reactivity considerations in detail below.
Structure: The molecule integrates a DBCO (dibenzocyclooctyne) cyclooctyne core, an amide-linked carbamate motif, and a PEG-based oligomeric spacer. It contains aromatic rings, amide and carbamate functional groups, and ether linkages, providing a flexible, hydrophilic scaffold suitable for conjugation chemistry.
Reactivity: DBCO groups participate in strain-promoted azide–alkyne cycloaddition with azides under copper-free conditions, enabling efficient conjugation without metal catalysts. The Fmoc carbamate supports stepwise synthesis and can be deprotected using standard base-mediated conditions used for Fmoc chemistry, followed by nucleophile coupling to form new amide or carbamate linkages. Solvent choice typically balances PEG solubility and compatibility with azide partners.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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