Lipoamido-PEG24-acid
Cat No.: BP-501779
4.5 
Lipoamido-PEG24-acid is a PEG-based, lipid-amidated linker acid designed for flexible conjugation in targeted protein degradation constructs. Structurally, it comprises a hydrophilic polyethylene glycol chain of extended length terminated with a carboxylic acid, and an amide-linked lipoamido (lipid-like) moiety that provides hydrophobic character while maintaining overall solubility. In PROTAC design, such linkers are used to spatially separate the ligand-binding warhead(s) from other functional modules, improving productive ternary complex formation by tuning effective reach and reducing steric constraints. The terminal acid enables straightforward coupling to activated derivatives of protein-binding ligands or to other linker fragments through amide-forming chemistries, facilitating modular assembly. This product is valuable for researchers seeking to optimize linker length and physicochemical balance, which can strongly influence degradation potency, cooperativity, and experimental tractability in PROTAC and related targeted degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Lipoamido-PEG24-acid is a polyethylene glycol–based linker designed for constructing PROTACs that require enhanced solubility and conformational flexibility between a target-binding ligand and an E3 ligase recruiter. Its amide-bearing PEG architecture supports efficient coupling chemistry and can help improve aqueous handling of conjugates. The following sections describe the linker’s structural features and the practical reaction considerations commonly used to assemble PROTACs with this scaffold.
Structure: The linker is built on a PEG chain terminated by a carboxylic acid and an amide (lipoamido) functionality. It contains ether linkages characteristic of PEG, plus stable amide and carboxyl groups, providing a flexible, hydrophilic, and hydrogen-bonding-capable scaffold suitable for bioconjugation.
Reactivity: The terminal carboxylic acid enables standard PROTAC linker coupling via amide-bond formation to nucleophilic amines on ligands. Typical approaches use carboxyl-activating reagents under mild base conditions, often in polar aprotic solvents, to form stable amide linkages. Mechanistically, activation of the acid followed by nucleophilic acyl substitution yields the conjugated PROTAC intermediate; catalyst choice and solvent selection should be optimized for ligand stability and desired coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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