m-PEG10-Br
Cat No.: BP-502055
4.5 
m-PEG10-Br is a monofunctional methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal bromide, providing a flexible, water-compatible chain for conjugation chemistry. Structurally, it consists of a PEG backbone with a defined ether repeat length and a bromomethyl end group that serves as an electrophilic handle for nucleophilic substitution or related coupling strategies. In PROTAC construction, such PEG linkers are commonly used to spatially separate the target-binding ligand and the E3 ligase-binding moiety, tuning effective intramolecular geometry, reducing steric clashes, and improving solubility and handling in aqueous assay conditions. The bromide end enables attachment to complementary nucleophiles (e.g., amines or thiols) to generate stable linker–ligand conjugates used in targeted protein degradation workflows. This product is valuable for researchers optimizing linker length and flexibility to balance ternary complex formation, degradation potency, and physicochemical properties during iterative PROTAC design.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG10-Br is a bromine-terminated polyethylene glycol linker designed for constructing PROTACs and related targeted protein degradation conjugates. Its ether-rich PEG scaffold provides aqueous compatibility and flexible spacing between binding and recruiting modules, supporting efficient ternary complex formation. The terminal bromide enables straightforward functionalization under standard organic synthesis conditions. The following points describe the linker’s structure and practical reactivity considerations in detail below.
Structure: The linker consists of a linear PEG chain featuring repeating ether units and a terminal aryl-bromide functionality. Its backbone is dominated by C–O ether linkages, imparting conformational flexibility, hydrophilicity, and reduced nonspecific hydrophobic interactions. The brominated terminus serves as a reactive handle for subsequent coupling.
Reactivity: The terminal bromide is suitable for nucleophilic substitution or related halide-displacement strategies commonly used to install PROTAC attachment groups. Typical approaches rely on polar aprotic solvents and controlled temperatures to promote substitution while minimizing PEG chain degradation or side reactions. Reaction design should consider nucleophile strength and steric accessibility, with base and catalyst selection guided by the electrophile–nucleophile pairing and the intended conjugation chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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