Name: Propargyl-PEG2-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥98.0%

Solubility

Soluble in DMSO

Appearance

Pale Yellow Oily Matter

ShelfLife

0-4°C for short term (days to weeks), or -20°C for long term (months).

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature, or blue ice upon request.

IUPACName

3-(2-prop-2-ynoxyethoxy)propanoic acid

Synonyms

Propyne-PEG1-CH2CH2COOH; 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid; 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid; Propargyl-PEG1-COOH; Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-

Boiling Point

306.6±27.0°C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

NNWHATPXNWOQKD-UHFFFAOYSA-N

InChI

InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10)

SMILES

C#CCOCCOCCC(=O)O

Biological Activity

Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	5.8079 mL	29.0394 mL	58.0788 mL
5 mM	1.1616 mL	5.8079 mL	11.6158 mL
10 mM	0.5808 mL	2.9039 mL	5.8079 mL

This Propargyl-PEG2-acid linker is designed for modular assembly of PROTACs, providing a flexible polyethylene glycol spacer that can improve solubility and spatial presentation between the target-binding ligand and the E3 ligase-recruiting moiety. The terminal propargyl functionality enables orthogonal conjugation strategies, while the carboxylic acid handle supports reliable coupling chemistries. Detailed structural and reactivity considerations are provided below to guide experimental PROTAC construction.

Structure: The linker comprises a short PEG segment bearing a terminal propargyl group and a carboxylic acid functionality. Its ether-rich backbone provides conformational flexibility, while the alkyne offers a reactive handle for bioorthogonal or derivatization reactions. The acid enables salt formation and controlled polarity.

Reactivity: The propargyl group is suitable for conjugation via alkyne-selective chemistries commonly used in bioconjugation workflows, including copper-catalyzed azide–alkyne cycloaddition and related click approaches where compatible. The carboxylic acid can be activated for amide or ester formation using standard coupling reagents under mild base/activator conditions, typically in polar organic solvents or mixed aqueous systems. Reaction design should account for PEG-mediated solubility and preserve functional-group compatibility during PROTAC synthesis.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂