m-PEG12-DBCO
Cat No.: BP-501729
Purity: 98%
4.5 
m-PEG12-DBCO is a methoxy-terminated polyethylene glycol linker bearing a DBCO (dibenzocyclooctyne) strained-alkyne for copper-free click chemistry. The PEG chain provides a hydrophilic, flexible spacer that improves solubility and reduces steric interference between the PROTAC components, while the DBCO group enables rapid, selective conjugation to azide-functionalized ligands or handles via strain-promoted azide–alkyne cycloaddition. In PROTAC design, this linker is used to connect or functionalize the targeting moiety and the E3-ligase-binding element (or a reporter/biotin tag) under mild aqueous conditions, allowing modular assembly and controlled stoichiometry without copper catalysts. Its PEG-based length and bioinert surface characteristics are particularly valuable for maintaining productive ternary complex formation and for facilitating downstream purification and characterization. Overall, m-PEG12-DBCO is a practical, research-grade tool for building and optimizing targeted protein degradation constructs with improved conjugation efficiency and experimental flexibility.
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* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
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| ConcentrationVolumeMass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.1806 mL | 5.9032 mL | 11.8064 mL |
| 5 mM | 0.2361 mL | 1.1806 mL | 2.3613 mL |
| 10 mM | 0.1181 mL | 0.5903 mL | 1.1806 mL |
m-PEG12-DBCO is a polyethylene glycol (PEG)-based bifunctional linker designed for efficient conjugation in PROTAC workflows, enabling rapid attachment of targeting ligands through strain-promoted azide–alkyne cycloaddition (SPAAC). Its PEG segment improves solubility and can reduce nonspecific interactions, supporting robust assembly of degraders under mild conditions. The subsequent points describe key structural features and practical reactivity considerations for constructing PROTACs using this linker.
Structure: This linker contains a PEG chain coupled to a cyclooctyne (DBCO) moiety, providing a rigid, strained alkyne for fast click chemistry. It features ether-rich segments that confer hydrophilicity, along with a cycloaddition-reactive functional group suitable for stable triazole formation.
Reactivity: m-PEG12-DBCO is used in SPAAC with azide-bearing partners to form a triazole linkage without added copper. Typical conditions employ aqueous or mixed aqueous buffers at mild temperature, where the strained DBCO reacts selectively with azides. No transition-metal catalyst is required, which helps preserve sensitive ligands and supports reproducible PROTAC assembly through a direct, high-yielding cycloaddition mechanism.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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