m-PEG48-Mal
Cat No.: BP-501925
4.5 
m-PEG48-Mal is a methoxy-capped PEG linker terminated with a maleimide group, providing a flexible, water-soluble tether of extended length suitable for bioconjugation. Structurally, it comprises a polyethylene glycol backbone that reduces nonspecific interactions and improves colloidal stability, while the terminal maleimide enables selective coupling to thiols via a Michael-type addition. In PROTAC and related targeted degradation workflows, such PEG–maleimide linkers are commonly used to connect or functionalize protein-binding ligands, warheads, or carrier scaffolds bearing cysteine/thiol handles, thereby positioning the two recognition elements at an appropriate spatial distance to promote productive ternary complex formation. Its value for targeted protein degradation research lies in facilitating modular synthesis and tunable linker geometry, which can help optimize degradation potency and selectivity while maintaining aqueous handling and minimizing aggregation.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG48-Mal is a polyethylene glycol (PEG) based maleimide linker designed to enable efficient conjugation in PROTAC workflows. Its maleimide functionality supports selective coupling to thiol-containing ligands, while the PEG spacer provides favorable solubility and reduced nonspecific interactions, helping maintain productive ternary complex formation. The points below describe the linker’s structural features and practical reactivity considerations for constructing targeted protein degraders.
Structure: The linker comprises a PEG chain terminated with a maleimide group, featuring a cyclic imide with an electron-deficient alkene. It contains ether linkages along the PEG backbone, providing hydrophilicity and conformational flexibility. The maleimide ring is suited for thiol addition, enabling stable thioether formation.
Reactivity: Maleimide–thiol coupling is typically performed under mild aqueous or mixed-solvent conditions near neutral pH to promote nucleophilic addition of thiols to the maleimide double bond. The reaction proceeds via a Michael-type addition followed by formation of a stable thioether linkage. Commonly used solvents include buffered aqueous media or compatible organic cosolvents, and no specialized catalysts are generally required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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