Aminooxy-PEG3-azide
CAS No.: 1306615-51-9
Cat No.: BP-500448
Purity: ≥98%
4.5 
Aminooxy-PEG3-azide is a heterobifunctional polyethylene glycol (PEG) linker featuring an aminooxy (–ONH2) reactive handle and a terminal azide group, connected through a short PEG3 chain that provides aqueous solubility and conformational flexibility. The aminooxy functionality enables oxime-bond formation with aldehyde-bearing targeting ligands, allowing stable conjugation under mild conditions, while the azide group serves as a bioorthogonal “click” partner for strain-promoted or copper-catalyzed azide–alkyne cycloaddition to attach complementary PROTAC modules such as warheads, E3-ligand fragments, or reporter tags. In PROTAC design, this combination supports modular assembly and controlled spatial separation between the binding moieties, which can improve ternary complex formation and degradation efficiency by reducing steric clashes. Researchers value Aminooxy-PEG3-azide for constructing well-defined, analytically tractable degraders and for rapid linker optimization across targeted protein degradation workflows.
Structure of 1306615-51-9
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Aminooxy-PEG3-azide is a bifunctional polyethylene glycol linker designed for modular PROTAC assembly, enabling efficient conjugation between targeting ligands and complementary reactive handles. Its aminooxy group supports oxime-forming chemistry, while the azide handle enables orthogonal click-type coupling, facilitating streamlined synthesis workflows and improved linker compatibility in targeted protein degradation constructs. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a PEG-based flexible chain that provides conformational mobility and aqueous compatibility, terminated by an aminooxy functional group and an azide moiety. It includes ether linkages characteristic of PEG and reactive heteroatom-containing termini suitable for bioorthogonal conjugation chemistry.
Reactivity: The aminooxy group can form oxime linkages with aldehyde-functional partners under mild, typically aqueous conditions, enabling stable attachment of one PROTAC module. The azide group participates in azide–alkyne cycloaddition with suitable alkyne partners, commonly using copper-free or copper-catalyzed systems depending on the substrate sensitivity. Solvent choice and reagent stoichiometry should be optimized to preserve ligand integrity and maximize coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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